The multifaceted mitochondrion: An attractive candidate for therapeutic strategies

被引：16
|
作者：
Strappazzon, Flavie [1 ,2 ]
Cecconi, Francesco [1 ,2 ,3 ]
机构：
[1] IRCCS Fdn Santa Lucia, I-00143 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[3] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, DK-2100 Copenhagen, Denmark
来源：
PHARMACOLOGICAL RESEARCH | 2015年 / 99卷
关键词：
Mitochondrial biogenesis; Mitochondrial quality control; Mitochondrial plasticity; DYNAMIN-RELATED GTPASE; EXTENDS LIFE-SPAN; STRESS-RESPONSE; CELL-DEATH; AUTOPHAGY; SIRT3; LONGEVITY; MITOPHAGY; FISSION; FUSION;
D O I：
10.1016/j.phrs.2015.03.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：425 / 433
页数：9
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