Short-term Safety of Covaxin, Sinopharm, Sputnik V, and AstraZeneca COVID-19 Vaccines Among Iranian Healthcare Workers: A Cross-sectional Study

被引:0
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作者
Sinaei, Reza [1 ,2 ]
Najafzadeh, Mohammad Javad [3 ]
Ghafari, Somayeh [2 ]
Hosseininasab, Ali [4 ]
Pardakhty, Abbas [5 ]
Dalfardi, Behnam [6 ]
Yousefi, Maysam [7 ]
Sinaei, Ali [8 ]
Pezeshki, Sara [2 ,9 ]
Sinaei, Roya [7 ,10 ]
Dehghani, Azam [11 ]
Robati, Fatemeh Karami [11 ]
Yeganeh, Mehrnoush Hassas [12 ]
Salajegheh, Faranak [13 ]
Goharriz, Fatemeh [14 ]
机构
[1] Kerman Univ Med Sci, Sch Med, Dept Pediat, Kerman, Iran
[2] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran
[3] Kerman Univ Med Sci, Student Res Comm, Kerman, Iran
[4] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran
[5] Kerman Univ Med Sci, Neuropharmacol Res Inst, Pharmaceut Res Ctr, Sch Pharm, Kerman, Iran
[6] Univ Tehran Med Sci, Adv Thorac Res Ctr, Tehran, Iran
[7] Kerman Univ Med Sci Iran, Afzalipour Hosp, Clin Res Dev Unit, Kerman, Iran
[8] Kerman Univ Med Sci, Sch Pharm, Kerman, Iran
[9] Kerman Univ Med Sci, Dept Internal Med, Sch Med, Kerman, Iran
[10] Univ Tehran Med Sci, Pediat Ctr Excellence, Childrens Med Ctr, Dept Pediat Neurol, Tehran, Iran
[11] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Gastroenterol & Hepatol Res Ctr, Kerman, Iran
[12] Shahid Beheshti Univ Med Sci, Tehran, Iran
[13] Kerman Univ Med Sci, Afzalipour Hosp, Sch Med, Dept Internal Med, Kerman, Iran
[14] Kerman Univ Med Sci, Kerman, Iran
来源
ARCHIVES OF CLINICAL INFECTIOUS DISEASES | 2024年 / 19卷 / 01期
关键词
COVID Vaccine; Side Effects; Health Care Workers; PREVALENCE;
D O I
10.5812/archcid-142157
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Several coronavirus disease 2019 (COVID-19) vaccines, utilizing different platforms, have successfully obtained emergency clinical use authorization to prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections. Most published data from COVID-19 vaccine trials have frequently observed mild -to -moderate side effects, with varying severity depending on various vaccine types. Objectives: This study aimed to estimate the prevalence of side effects associated with four types of COVID-19 vaccines among vaccinated healthcare workers following the first and second vaccine doses and to identify possible risk factors for COVID-19 vaccine side effects. Methods: This cross-sectional study was conducted from April 2021 to March 2022 by administering a questionnaire and conducting direct interviews with healthcare workers in Kerman, southeastern Iran, who had received 2 or more doses of COVID-19 vaccines. Results: Out of 861 individuals enrolled in the study, 38.7% received Sputnik, 32.4% AstraZeneca, 19.6% Covaxin, and 9.3% Sinopharm vaccines. Overall, the most common side effects after the first and second doses included general symptoms, fever and chills, injection site reactions, neurological symptoms, and gastrointestinal symptoms. Furthermore, the frequency of symptoms significantly reduced after the second dose. Conclusions: General symptoms and injection site reactions were significantly more common after receiving the first dose of vaccines compared to the second dose. No severe vaccine side effects were observed in this study. However, further research is required to evaluate the long-term symptoms and safety profiles of COVID-19 vaccines.
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页数:11
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