FAM19A5 in vascular aging and osteoporosis: Mechanisms and the "calcification paradox"

被引：0
|
作者：
Zheng, Jin [1 ]
He, Jieyu [2 ]
Li, Huahua [1 ,3 ]
机构：
[1] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Geriatr, Affiliated Hosp 1, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Geriatr, Changsha, Hunan, Peoples R China
[3] Hunan Normal Univ, Hunan Prov People symbolscript Hosp, Dept Geriatr, Affiliated Hosp 1, Changsha 410005, Hunan, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2024年 / 99卷
关键词：
Vascular aging; Vascular smooth muscle cells; Osteoporosis; Tumor; SMOOTH-MUSCLE-CELLS; BONE-MINERAL DENSITY; KAPPA-B LIGAND; RECEPTOR ACTIVATOR; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; NEUROVASCULAR UNIT; RANKL; EXPRESSION; OSTEOPROTEGERIN;
D O I：
10.1016/j.arr.2024.102361
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging induces a progressive decline in the vasculature's structure and function. Vascular aging is a determinant factor for vascular ailments in the elderly. FAM19A5, a recently identified adipokine, has demonstrated involvement in multiple vascular aging-related pathologies, including atherosclerosis, cardio-cerebral vascular diseases and cognitive deficits. This review summarizes the current understanding of FAM19A5' role and explores its putative regulatory mechanisms in various aging-related disorders, including cardiovascular diseases (CVDs), metabolic diseases, neurodegenerative diseases and malignancies. Importantly, we provide novel insights into the underlying therapeutic value of FAM19A5 in osteoporosis. Finally, we outline future perspectives on the diagnostic and therapeutic potential of FAM19A5 in vascular aging-related diseases.
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页数：11
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共 37 条
  • [21] FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma
    Wang, Yanfang
    Zhang, Zhenhao
    Wan, Wei
    Liu, Yan
    Jing, Hongmei
    Dong, Fei
    [J]. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2022, 42 (03) : 225 - 229
  • [22] FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice
    Huang, Shiyang
    Zheng, Can
    Xie, Guoguang
    Song, Zhanming
    Wang, Pingzhang
    Bai, Yun
    Chen, Dixin
    Zhang, Yan
    Lv, Ping
    Liang, Weiwei
    She, Shaoping
    Li, Qingqing
    Liu, Zhongtian
    Wang, Yun
    Xing, Guo-Gang
    Wang, Ying
    [J]. MOLECULAR PSYCHIATRY, 2021, 26 (06) : 2363 - 2379
  • [23] FAM19A5在套细胞淋巴瘤患者中的表达及其临床意义
    王艳芳
    黄诗扬
    张朕豪
    董菲
    王应
    景红梅
    克晓燕
    [J]. 中国实验血液学杂志, 2020, 28 (04) : 1183 - 1188
  • [24] Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2
    Wang, Yingbao
    Chen, Dixin
    Zhang, Yan
    Wang, Pingzhang
    Zheng, Can
    Zhang, Songyang
    Yu, Bing
    Zhang, Lu
    Zhao, Guizhen
    Ma, Baihui
    Cai, Zeyu
    Xie, Nan
    Huang, Shiyang
    Liu, Ziyi
    Mo, Xiaoning
    Guan, Youfei
    Wang, Xian
    Fu, Yi
    Ma, Dalong
    Wang, Ying
    Kong, Wei
    [J]. CIRCULATION, 2018, 138 (01) : 48 - 63
  • [25] FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2
    Park, Min Young
    Kim, Hyung Sik
    Lee, Mingyu
    Park, Byunghyun
    Lee, Ha Young
    Cho, Eun Bee
    Seong, Jae Young
    Bae, Yoe-Sik
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [26] FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2
    Min Young Park
    Hyung Sik Kim
    Mingyu Lee
    Byunghyun Park
    Ha Young Lee
    Eun Bee Cho
    Jae Young Seong
    Yoe-Sik Bae
    [J]. Scientific Reports, 7
  • [27] FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice
    Shiyang Huang
    Can Zheng
    Guoguang Xie
    Zhanming Song
    Pingzhang Wang
    Yun Bai
    Dixin Chen
    Yan Zhang
    Ping Lv
    Weiwei Liang
    Shaoping She
    Qingqing Li
    Zhongtian Liu
    Yun Wang
    Guo-Gang Xing
    Ying Wang
    [J]. Molecular Psychiatry, 2021, 26 : 2363 - 2379
  • [28] Development and Validation of a Plasma FAM19A5 and MRI-Based Radiomics Model for Prediction of Parkinson's Disease and Parkinson's Disease With Depression
    Li, Xue-ning
    Hao, Da-peng
    Qu, Mei-jie
    Zhang, Meng
    Ma, An-bang
    Pan, Xu-dong
    Ma, Ai-jun
    [J]. FRONTIERS IN NEUROSCIENCE, 2021, 15
  • [29] Identification of psoriasis-protective IL-17D variant associated with increased IL-17D and FAM19A5 expression in psoriatic skin
    Toussi, Atrin
    Merleev, Alexander
    Barton, Virginia
    Le, Stephanie
    Marusina, Alina I.
    Luxardi, Guillaume
    Tsoi, Lam
    Gudjonsson, Johann E.
    Maverakis, Emanual
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 83 (06) : AB78 - AB78
  • [30] Fetuin-A, osteoporosis and inflammation-proposal of possible mechanisms for vascular and valvular calcification in chronic kidney disease Reply
    Smith, Edward R.
    Ford, Martin L.
    Tomlinson, Laurie A.
    Rajkumar, Chakravarthi
    Holt, Stephen G.
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (08) : 2801 - 2802
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