Diabetes and the fabkin complex: A dual-edged sword

被引:0
|
作者
Khan, Safir Ullah [1 ]
Hernandez-Gonzalez, Karla Daniela [2 ]
Ali, Amir [3 ]
Rizvi, Syed Shakeel Raza [1 ]
机构
[1] Pir Mehr Ali Shah Arid Agr Univ, Fac Sci, Dept Zool Wildlife & Fisheries, Rawalpindi 46300, Pakistan
[2] Univ Veracruzana, Fac Biol, Zona Univ,Circuito Gonzalo Aguirre Beltran s-n, Xalapa 91000, Veracruz, Mexico
[3] Ctr Res & Adv Studies IPN, Nanosci & Nanotechnol Program, Mexico City, Mexico
关键词
FABP4; ADK; NDPK; Fabkin; Diabetes; ACID-BINDING PROTEIN; PANCREATIC BETA-CELL; NUCLEOSIDE DIPHOSPHATE KINASE; ADENOSINE A(2A) RECEPTOR; INSULIN-RESISTANCE; CANCER CELLS; EXPRESSION; ACTIVATION; METABOLISM; OBESITY;
D O I
10.1016/j.bcp.2024.116196
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The Fabkin complex, composed of FABP4, ADK, and NDPKs, emerges as a novel regulator of insulin-producing beta cells, offering promising prospects for diabetes treatment. Our approach, which combines literature review and database analysis, sets the stage for future research. These findings hold significant implications for both diabetes treatment and research, as they present potential therapeutic targets for personalized treatment, leading to enhanced patient outcomes and a deeper comprehension of the disease. The multifaceted role of the Fabkin complex in glucose metabolism, insulin resistance, anti-inflammation, beta cell proliferation, and vascular function underscores its therapeutic potential, reshaping diabetes management and propelling advancements in the field.
引用
收藏
页数:16
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