Biological window excited up-conversion persistent luminescence nanoparticles for bioimaging and photodynamic therapy

被引：0

作者：

Liu, Lin ^{[1
,2
]}

Huang, Kaiyan ^{[1
,5
]}

Yin, Xianggui ^{[2
]}

Wang, Jinyuan ^{[2
]}

Gao, Yan ^{[2
]}

Shi, Junpeng ^{[2
,3
]}

Zhang, Fangrong ^{[4
]}

Sun, Xia ^{[3
]}

Zheng, Chaohui ^{[1
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 2, Quanzhou 362000, Peoples R China

[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China

[3] Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350108, Peoples R China

[4] Fujian Med Univ, Sch Basic Med Sci, Key Lab Gastrointestinal Canc, Minist Educ, Fuzhou 350122, Peoples R China

[5] Fujian Med Univ, Affiliated Hosp 2, Dept Breast & Thyroid Surg, Quanzhou 362000, Peoples R China

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2024年 / 28卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Up-conversion luminescence; Persistent luminescence; Bioimaging; Photodynamic therapy;

D O I：

10.1016/j.jscs.2024.101893

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have inherent advantages for high-sensitivity bioimaging due to the separation of excitation and emission light. However, the single-wavelength emission of NIR PLNPs for bioimaging limits their use in photodynamic therapy (PDT). Herein, a biological window excited up-conversion (UC) PLNPs, Zn3Ga2SnO8:Cr3+,Yb3+,Ho3+ (ZGS), was reported for bioimaging and PDT. ZGS exhibits NIR persistent luminescence (PersL) after red LED excitation and visible UCL under 980 nm excitation. The NIR PersL is designed for in vivo bioimaging; the visible UCL is used to activate photosensitizer (PS) to generate reactive oxygen species (ROS) for PDT. The dual-functional ZGS with UCL and PersL provides an effective method for bioimaging and PDT, which is expected to further promote the application of PLNPs in the integration of efficient diagnosis and treatment.

引用

页数：7

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