Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

被引：1

作者：

Marinova, Petya ^{[1
]}

Burdzhiev, Nikola ^{[2
]}

Blazheva, Denica ^{[3
]}

Slavchev, Aleksandar ^{[3
]}

机构：

[1] Paisij Hilendarski Univ Plovdiv, Fac Chem, Dept Gen & Inorgan Chem Methodol Chem Educ, Tzar Assen Str 24, Plovdiv 4000, Bulgaria

[2] Univ Sofia, Fac Chem & Pharm, Dept Organ Chem & Pharmacognosy, 1 J Bourchier Ave, Sofia 1164, Bulgaria

[3] Univ Food Technol, Dept Microbiol, 26 Maritza Blvd, Plovdiv 4002, Bulgaria

来源：

MOLBANK | 2024年 / 2024卷 / 02期

关键词：

antimicrobial activity; gold(III) complexes; 6-methyl-2-thiouracil (6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one); 2-THIOURACIL; GOLD;

D O I：

10.3390/M1827

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article describes the synthesis of a new metal complex using 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one. The compound was analyzed using several methods, including determining its melting point and employing UV-Vis, IR, ATR, H-1 NMR, HSQC, and Raman spectroscopy for the free ligand. The metal complex was formed by combining aqueous solutions of metal salts with the ligand dissolved in DMSO and water, along with NaOH in a metal-to-ligand-to-base ratio of 1:4:2. The NMR signals of the ligand were assigned using H-1-H-1 COSY, DEPT-135, HMBC, and HMQC spectra. Furthermore, the compound's antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeasts, was assessed.

引用

页数：12

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