Design, Synthesis and Anticancer Evaluation of Benzoxazole Resemble Substituted Arylamide Derivatives of Bis-1,3,4-Oxadiazole-oxazolo[4,5-b]pyridin-2-yl) as Anticancer Agents

被引：0
|
作者：
Syeda, Arshiya Banu [1 ]
Syeda, Asra Banu [2 ]
Ferazoddin, Mohammad [1 ]
Rajeswari, M. [3 ]
Paul, J. P. [1 ]
Juluru, Bhasker [1 ]
机构：
[1] Chaitanya Deemed Be Univ, Dept Chem, Hanamkonda 506001, Telangana, India
[2] Jazan Univ, Dept Chem, Jazan, Saudi Arabia
[3] Telangana Univ, Organ Chem Dept, Nizamabad, Telangana, India
来源：
CHEMICAL DATA COLLECTIONS | 2023年 / 43卷
关键词：
Benoxaprofen; IMATINIB; Benzoxazole; Pyrimidine and anticancer activity; BIOLOGICAL EVALUATION; 1,3,4-OXADIAZOLE; BENZIMIDAZOLE;
D O I：
10.1016/j.cdc.2022.100971
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A unique library of amide functionality carrying bis-1,3,4-oxadiazole-oxazolo[4,5-b]pyridin-2-yl) derivatives (10a -j) with proven chemical structures has been synthesised. They were tested for preliminary anticancer properties against various human cancer cell lines such as human prostate cancer (PC3), human lung cancer (A549), human breast cancer (MCF-7) and human colon cancer (Colo -205) using the MTT assay and chemotherapeutic agents such as etoposide as the reference drug. When compared to etoposide, all drugs shown greater efficacy against all cell lines.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] Design, synthesis and biological evaluation of isoxazole bearing 1, 3-oxazole-1, 3, 4-oxadiazole derivatives as anticancer agents
    Lingala, Arun Kumar
    Murahari, Kiran Kumar
    Desireddi, Janardana Reddi
    Mothe, Thirupathi
    Maiti, Bhimcharan
    Manchal, Ravinder
    CHEMICAL DATA COLLECTIONS, 2023, 43
  • [32] Quantitative structure–activity relationships (QSARs) and pharmacophore modeling for human African trypanosomiasis (HAT) activity of pyridyl benzamides and 3-(oxazolo[4,5-b]pyridin-2-yl)anilides
    Vijay H. Masand
    Devidas T. Mahajan
    Atish K. Maldhure
    Vesna Rastija
    Medicinal Chemistry Research, 2016, 25 : 2324 - 2334
  • [33] Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents
    Almalki, Abdulraheem S. A.
    Nazreen, Syed
    Malebari, Azizah M.
    Ali, Nada M.
    Elhenawy, Ahmed A.
    Alghamdi, Abdullah A. A.
    Ahmad, Abrar
    Alfaifi, Sulaiman Y. M.
    Alsharif, Meshari A.
    Alam, Mohammad Mahboob
    PHARMACEUTICALS, 2021, 14 (09)
  • [34] Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Antibacterial Agents
    Em Canh Pham
    Tuyen Ngoc Truong
    Nguyen Hanh Dong
    Duy Duc Vo
    Tuoi Thi Hong Do
    MEDICINAL CHEMISTRY, 2022, 18 (05) : 558 - 573
  • [35] 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents
    Kirwen, Erin Marie
    Batra, Tarun
    Karthikeyan, Chandrabose
    Deora, Girdhar Singh
    Rathore, Vandana
    Mulakayala, Chaitanya
    Mulakayala, Naveen
    Nusbaum, Amy Catherine
    Chen, Joel
    Amawi, Haneen
    McIntosh, Kyle
    Sahabjada
    Shivnath, Neelam
    Chowarsia, Deepak
    Sharma, Nisha
    Arshad, Md
    Trivedi, Piyush
    Tiwari, Amit K.
    ACTA PHARMACEUTICA SINICA B, 2017, 7 (01) : 73 - 79
  • [36] 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents
    Erin Marie Kirwen
    Tarun Batra
    Chandrabose Karthikeyan
    Girdhar Singh Deora
    Vandana Rathore
    Chaitanya Mulakayala
    Naveen Mulakayala
    Amy Catherine Nusbaum
    Joel Chen
    Haneen Amawi
    Kyle Mc Intosh
    Sahabjada
    Neelam Shivnath
    Deepak Chowarsia
    Nisha Sharma
    Md Arshad
    Piyush Trivedi
    Amit K.Tiwari
    Acta Pharmaceutica Sinica B, 2017, 7 (01) : 73 - 79
  • [37] Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives
    Akbay, A
    Ören, I
    Temiz-Arpaci, Ö
    Aki-Sener, E
    Yalçin, I
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2003, 53 (04): : 266 - 271
  • [38] Design, synthesis, and biological evaluation of 1-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives as anticancer agents
    Aghcheli, Ayoub
    Toolabi, Mahsa
    Ayati, Adileh
    Moghimi, Setareh
    Firoozpour, Loghman
    Bakhshaiesh, Tayebeh Oghabi
    Nazeri, Elahe
    Norouzbahari, Maryam
    Esmaeili, Rezvan
    Foroumadi, Alireza
    MEDICINAL CHEMISTRY RESEARCH, 2020, 29 (11) : 2000 - 2010
  • [39] Design, synthesis, and biological evaluation of 1-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives as anticancer agents
    Ayoub Aghcheli
    Mahsa Toolabi
    Adileh Ayati
    Setareh Moghimi
    Loghman Firoozpour
    Tayebeh Oghabi Bakhshaiesh
    Elahe Nazeri
    Maryam Norouzbahari
    Rezvan Esmaeili
    Alireza Foroumadi
    Medicinal Chemistry Research, 2020, 29 : 2000 - 2010
  • [40] SYNTHESIS OF NEW 2, 5, 6-SUBSTITUTED IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
    Sethi, Navdeep Singh
    Noolvi, Malleshappa N.
    Kharb, Vandana
    Nathubhai, Vinay K.
    More, Uttam A.
    Avvaru, Stephen Paul
    Khairnar, Bhikan J.
    Desai, Shivali
    Thippeswamy, B. S.
    Al Otaibi, Faisal
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (11): : 5518 - 5529
12345