Functional genetics of APR-246 rescuable TP53 mutants

被引:0
|
作者
Saunders, Anais
Tong, Caili
Karnezis, Anthony N.
Leiserowitz, Gary S.
Chein, Jeremy R.
机构
关键词
D O I
10.1158/1538-7445.AM2024-631
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
631
引用
收藏
页数:2
相关论文
共 50 条
  • [1] APR-246 cytotoxic effects are TP53 independent in endometrial cancer cell lines
    Yu, Camilla
    Petty, Aaron
    Vargas, Roberto
    CANCER RESEARCH, 2023, 83 (07)
  • [2] Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
    Abrams, Stephen L.
    Duda, Przemyslaw
    Akula, Shaw M.
    Steelman, Linda S.
    Follo, Matilde L.
    Cocco, Lucio
    Ratti, Stefano
    Martelli, Alberto M.
    Montalto, Giuseppe
    Emma, Maria Rita
    Cervello, Melchiorre
    Rakus, Dariusz
    Gizak, Agnieszka
    McCubrey, James A.
    CELLS, 2022, 11 (05)
  • [3] Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes
    Sallman, David A.
    DeZern, Amy E.
    Garcia-Manero, Guillermo
    Steensma, David P.
    Roboz, Gail J.
    Sekeres, Mikkael A.
    Cluzeau, Thomas
    Sweet, Kendra L.
    McLemore, Amy
    McGraw, Kathy L.
    Puskas, John
    Zhang, Ling
    Yao, Jiqiang
    Mo, Qianxing
    Nardelli, Lisa
    Al Ali, Najla H.
    Padron, Eric
    Korbel, Greg
    Attar, Eyal C.
    Kantarjian, Hagop M.
    Lancet, Jeffrey E.
    Fenaux, Pierre
    List, Alan F.
    Komrokji, Rami S.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (14) : 1584 - +
  • [4] The Impact of TP53 Mutations and Use of the TP53Mutation-Reactivating Agent APR-246 on Metastatic Castrate-Sensitive Prostate Cancer
    Hoang, T.
    Sutera, P.
    Nguyen, T.
    Chang, J. H.
    Jagtap, S.
    Song, Y.
    Shetty, A.
    Chowdhury, D. D.
    Chan, A.
    Carrieri, F. A. A.
    Song, D.
    DeWeese, T. L.
    Lafargue, A.
    Van der Eecken, K.
    Bunz, F.
    Ost, P.
    Tran, P. T.
    Deek, M. P.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 117 (02): : E443 - E443
  • [5] To target the untargetable: elucidation of synergy of APR-246 and azacitidine in TP53 mutant myelodysplastic syndromes and acute myeloid leukemia
    Sallman, David A.
    HAEMATOLOGICA, 2020, 105 (06) : 1470 - 1472
  • [6] SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status
    Fujihara, Kenji M.
    Benitez, Mariana Corrales
    Cabalag, Carlos S.
    Zhang, Bonnie Z.
    Ko, Hyun S.
    Liu, David S.
    Simpson, Kaylene J.
    Haupt, Ygal
    Lipton, Lara
    Haupt, Sue
    Phillips, Wayne A.
    Clemons, Nicholas J.
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (10) : 1858 - 1867
  • [7] The impact of TP53 mutations and use of the TP53-mutation-reactivating agent APR-246 on metastatic castrate-sensitive prostate cancer.
    Hoang, Tung
    Sutera, Philip
    Nguyen, Triet
    Chang, Jin Hee
    Jagtap, Shreya
    Song, Yang
    Shetty, Amol
    Chowdhury, Dipanwita
    Chan, Aaron
    Carrieri, Francesca Anna
    Song, Daniel Y.
    DeWeese, Theodore L.
    Lafargue, Audrey
    Van der Eecken, Kim
    Ost, Fred Bunz Piet
    Tran, Phuoc T.
    Deek, Matthew
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [8] APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations
    Yuheng Hong
    Tianyuan Ren
    Xiaoxuan Wang
    Xia Liu
    Yue Fei
    Shen Meng
    Xu Han
    Cong Sun
    Hongru Shen
    Lanfang Li
    Lihua Qiu
    Zhengzi Qian
    Shiyong Zhou
    Huilai Zhang
    Xianhuo Wang
    Leukemia, 2022, 36 : 2269 - 2280
  • [9] TP53 structure-function relationships in metastatic castrate-sensitive prostate cancer and the impact of APR-246 treatment
    Hoang, Tung
    Sutera, Philip
    Nguyen, Triet
    Chang, Jinhee
    Jagtap, Shreya
    Song, Yang
    Shetty, Amol C.
    Chowdhury, Dipanwita D.
    Chan, Aaron
    Carrieri, Francesca A.
    Hathout, Lara
    Ennis, Ronald
    Jabbour, Salma K.
    Parikh, Rahul
    Molitoris, Jason
    Song, Daniel Y.
    DeWeese, Theodore
    Marchionni, Luigi
    Ren, Lei
    Sawant, Amit
    Simone, Nicole
    Lafargue, Audrey
    Van Der Eecken, Kim
    Bunz, Fred
    Ost, Piet
    Tran, Phuoc T.
    Deek, Matthew P.
    PROSTATE, 2024, 84 (01): : 87 - 99
  • [10] APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations
    Hong, Yuheng
    Ren, Tianyuan
    Wang, Xiaoxuan
    Liu, Xia
    Fei, Yue
    Meng, Shen
    Han, Xu
    Sun, Cong
    Shen, Hongru
    Li, Lanfang
    Qiu, Lihua
    Qian, Zhengzi
    Zhou, Shiyong
    Zhang, Huilai
    Wang, Xianhuo
    LEUKEMIA, 2022, 36 (09) : 2269 - 2280