Management of Dry Eye Toxicity After Treatment With 177Lu-PSMA-617 Radioligand Therapy

被引：0
|
作者：
Pepin, Abigail [1 ]
Lee, Vivian [2 ]
O'Brien, Sophia [3 ]
Mulugeta, Philipose [3 ]
Taunk, Neil K. [1 ]
机构：
[1] Hosp Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[2] Hosp Univ Penn, Dept Ophthalmol, Philadelphia, PA USA
[3] Hosp Univ Penn, Div Nucl Med, Philadelphia, PA USA
来源：
PRACTICAL RADIATION ONCOLOGY | 2024年 / 14卷 / 04期
关键词：
SALIVARY; GLANDS;
D O I：
10.1016/j.prro.2024.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment options for patients with metastatic castration-resistant prostate cancer include use of radioligand therapy with 177LuPSMA-617. 177Lu-PSMA-617 is used to target prostate cancer cells selectively by targeting prostate specific membrane antigen (PSMA); however, PSMA is also expressed on lacrimal glands among other tissues. Herein, we report on a case of a Common Terminology Criteria for Adverse Events version 5 grade 3 dry eye event with concomitant blepharitis after administration of 177Lu-PSMA-617. The patient was managed with neomycin-polymyxin-dexamethasone 3.5-10000-0.1 ophthalmic suspension, artificial tears, lubricating ointments, lid scrubs, and oral antihistamines. (c) 2024 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.
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页码：301 / 304
页数：4
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