Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure

被引：3

作者：

Yuan, Yexian ^{[1
,2
]}

Hu, Ruoci ^{[1
,3
]}

Park, Jooman ^{[1
]}

Xiong, Shaolei ^{[1
]}

Wang, Zilai ^{[4
]}

Qian, Yanyu ^{[1
]}

Shi, Zuoxiao ^{[1
,3
]}

Wu, Ruifan ^{[1
,5
,6
]}

Han, Zhenbo ^{[7
]}

Ong, Sang-Ging ^{[7
,8
]}

Lin, Shuhao ^{[9
]}

Varady, Krista A. ^{[9
]}

Xu, Pingwen ^{[10
]}

Berry, Daniel C. ^{[11
]}

Shu, Gang ^{[5
,6
]}

Jiang, Yuwei ^{[1
,3
,10
]}

机构：

[1] Univ Illinois, Coll Med, Dept Physiol & Biophys, Chicago, IL 60612 USA

[2] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China

[3] Univ Illinois, Dept Pharmaceut Sci, Chicago, IL 60612 USA

[4] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA

[5] South China Agr Univ, Coll Anim Sci, Guangdong Lab Lingnan Modern Agr, Guangdong Prov Key Lab Anim Nutr Regulat, Guangzhou 510642, Peoples R China

[6] South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China

[7] Univ Illinois, Dept Pharmacol & Regenerat Med, Coll Med, Chicago, IL 60612 USA

[8] Univ Illinois, Dept Med, Div Cardiol, Chicago, IL 60612 USA

[9] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60612 USA

[10] Univ Illinois, Dept Med, Div Endocrinol, Chicago, IL 60612 USA

[11] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 26期

关键词：

BROWN ADIPOSE-TISSUE; ALTERNATIVELY ACTIVATED MACROPHAGES; INFLAMMATORY MONOCYTES; LYMPHOID-CELLS; FAT; WHITE; EOSINOPHILS; RECEPTOR; VIVO; CONTRIBUTE;

D O I：

10.1126/sciadv.adn5229

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT. CCL22 injection into iWAT effectively promotes iWAT beiging, while blocking CCL22 with antibodies can prevent it. Mechanistically, the CCL22 receptor, C-C motif chemokine receptor 4 (CCR4), within eosinophils and its downstream focal adhesion kinase/p65/interleukin-4 signaling are essential for CCL22-mediated beige adipocyte formation. Moreover, CCL22 levels are inversely correlated with body weight and fat mass in mice and humans. Acute elevation of CCL22 levels effectively prevents diet-induced body weight and fat gain by enhancing adipose beiging. Together, our data identify the CCL22-CCR4 axis as an essential mediator for LN-controlled adaptive thermogenesis and highlight its potential to combat obesity and its associated complications.

引用

页数：22

共 32 条

[31] Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue
Katou, F
Ohtani, H
Nakayama, T
Ono, K
Matsushima, K
Saaristo, A
Nagura, H
Yoshie, O
Motegi, K
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (04): : 1263 - 1270
[32] RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4
Eliane Shizuka Nakamura
Keiichi Koizumi
Mitsuo Kobayashi
Yurika Saitoh
Yoshihisa Arita
Takashi Nakayama
Hiroaki Sakurai
Osamu Yoshie
Ikuo Saiki
Clinical & Experimental Metastasis, 2006, 23 : 9 - 18

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