Palladium-catalyzed arylative benzannulation of 4-alkynyl-3-alkenyl indoles with arylboronic acids to benzo[cd]indoles

被引：0
|
作者：
Sathish, Puppala [1 ,2 ]
Subbarao, Muppidi [1 ,2 ]
Prapurna, Y. Lakshmi [1 ]
机构：
[1] CSIR Indian Inst Chem Technol, Hyderabad 500007, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201 002, India
来源：
CHEMICAL DATA COLLECTIONS | 2022年 / 39卷
关键词：
4-alkynyl-3-alkenyl indoles; Carbometalation of alkyne; Intramolecular michael addition; Arylboronic acids; Benzo[cd]indoles; C-H ACTIVATION; INTRAMOLECULAR ANNULATION; ALKYNE ANNULATION; BOND ACTIVATION; CYCLIZATION; INHIBITORS; DESIGN; DYES; HYDROAMINATION; CONSTRUCTION;
D O I：
10.1016/j.cdc.2022.100865
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new protocol employing arylative sequential reaction of alkynes with boronic acids in one-pot has been developed to access benzo[cd]indoles as products via carbometalation of alkyne followed by intramolecular Michael addition. The one-pot reaction of 4-alkynyl-3-alkenyl indoles bearing a Michael acceptor at the 3-position with boronic acids catalyzed by palladium/triflic acid furnished the products through intramolecular dearomative-aromatization (benzannulation).
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页数：10
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