Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils

被引：0
|
作者：
Orallo, Dalila E. [1 ,4 ]
Fuentes, Giselle M. [3 ,4 ]
Benavidez, Maria G. [1 ]
Suarez, Patricia A. [5 ]
Nutter, Diego [6 ]
Fangio, Maria F. [1 ,2 ]
Ramirez, Cristina L. [1 ]
机构：
[1] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, CONICET, Dept Quim & Bioquim, Funes 3350, F-7600 Mar Del Plata, Buenos Aires, Argentina
[2] Inst Invest Fis Mar del Plata, IFIMAR CONICET UNMDP, Funes 3350, RA-7600 Mar Del Plata, Argentina
[3] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Ctr Cient Tecnol Mar del Plata, Inst Invest Prod Sanidad & Ambiente IIPROSAM,Ctr A, Mar Del Plata, Argentina
[4] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Ctr Invest Abejas Sociales, Mar Del Plata, Argentina
[5] FCEyN UNMdP CONICET, Inst Invest Marinas & Costeras IIMyC, Juan B Justo 2550, Mar Del Plata, Argentina
[6] ONG CBG2000, San Luis 1986, RA-7600 Mar Del Plata, Buenos Aires, Argentina
来源：
FITOTERAPIA | 2024年 / 177卷
关键词：
Long-term stability; Cannabis oil; Galenic formulations; Total polyphenol content; Antioxidant capacity; ANTIMICROBIAL ACTIVITY; EXTRACTS;
D O I：
10.1016/j.fitote.2024.106128
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The long-term stability in real and accelerated time for galenic oils based on full-spectrum cannabis has been studied, using sesame oil as a dilutant. Sesame oil is one of the most used vehicles in the cannabis pharmaceutical industry due to the costs and increased oral bioavailability of cannabinoids. The real-time assays conducted at 25 degrees C over twelve months demonstrated high stability and showed no significant changes in the composition of cannabinoids, total polyphenols, flavonoids, or antioxidant capacity. In these studies, it was observed that there was no development of microorganisms compromising the stability of the oils over a year. The three oil varieties exhibited a high bactericidal capacity against E. coli, S. aureus, and P. larvae.
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页数：8
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