Benign-by-design sustainable protocol for the synthesis of furosemide

被引：0

作者：

Minio, Francesco ^{[1
]}

Torriente, Airovict Hernandez ^{[2
]}

Balu, Alina M. ^{[2
]}

Vaccaro, Luigi ^{[1
]}

Osman, Sameh M. ^{[3
]}

Luque, Rafael ^{[4
,5
]}

Chhabra, Tripti ^{[2
]}

机构：

[1] Univ Perugia, Dipartimento Chim Biol & Biotecnol, Via Elce di Sotto 8, I-06123 Perugia, Italy

[2] Univ Cordoba, Dept Quim Organ, Ctra Nnal 4 A,Km 396, E-14014 Cordoba, Spain

[3] King Saud Univ, Coll Sci, Chem Dept, POB 2455, Riyadh 11451, Saudi Arabia

[4] Peoples Friendship Univ Russia RUDN Univ, 6 Miklukho Maklayastr, Moscow, Russia

[5] ECOTEC, Km 13-5 Samborondon, EC-092302 Samborondon, Ecuador

来源：

SUSTAINABLE CHEMISTRY AND PHARMACY | 2024年 / 39卷

关键词：

Biomass; Active pharmaceutical ingredients; Furan derivatives; Furosemide; Microwave irradiation; GREEN CHEMISTRY; SUBSTITUTION REACTIONS; BIOMASS; SOLVENT; METRICS;

D O I：

10.1016/j.scp.2024.101600

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study discloses a benign -by -design synthetic protocol for furosemide using a biomassderived active pharmaceutical ingredient. The optimized protocol, designed for efficiency, was implemented within an hour using a microwave reactor and a range of environmentally friendly solvents. Investigations were carried out to assess the influence of additives and reaction media on the synthesis process. Green metrics were measured to propose an environmentally sound protocol aiming to minimize waste generation. These findings advance the development of a sustainable and efficient synthesis route for furosemide.

引用

页数：6

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