Construction of [1,4]oxazepin-2-ones via catalyst-free intramolecular C-O bond formation from Ugi adducts

被引：2

作者：

Mirfattahi, Mahroo ^{[1
]}

Yazzaf, Rozita ^{[1
]}

Mahdavi, Mohammad ^{[2
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, POB 14155-6455, Tehran, Iran

[2] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2024年 / 141卷

关键词：

Post-Ugi cyclization; 1; 4]oxazepin-2-ones; Multicomponent reaction; Bromoacetic acid; Catalyst; -free; MULTICOMPONENT REACTIONS; HETEROCYCLES; CYCLIZATION; CHEMISTRY;

D O I：

10.1016/j.tetlet.2024.155075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cyclization of Ugi adducts through a base-mediated system has been reported. The process entails an oxygen nucleophilic attack on the alkyl halide moiety, subsequently leading to an intramolecular cyclization. These consecutive reactions are straightforward to execute, occur under mild conditions, and do not require a catalyst. This catalyst-free attribute enhances the method's utility and eco-friendliness, rendering it an appealing approach for producing this significant category of heterocyclic compounds.

引用

页数：4

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