Experimental infection of cattle, sheep, and goats with the newly emerged epizootic hemorrhagic disease virus serotype 8

被引:5
|
作者
Spedicato, Massimo [1 ]
Profeta, Francesca [1 ]
Thabet, Sarah [2 ]
Teodori, Liana [1 ]
Leone, Alessandra [1 ]
Portanti, Ottavio [1 ]
Pisciella, Maura [1 ]
Bonfini, Barbara [1 ]
Pulsoni, Simone [1 ]
Rosso, Francesca [1 ]
Rossi, Emanuela [1 ]
Ripa, Paola [1 ]
De Rosa, Angela [1 ]
Ciarrocchi, Eugenia [1 ]
Irelli, Roberta [1 ]
Cocco, Antonio [1 ]
Sailleau, Corinne [3 ]
Ferri, Nicola [1 ]
Di Febo, Tiziana [1 ]
Vitour, Damien [3 ]
Breard, Emmanuel [3 ]
Giansante, Daniele [1 ]
Sghaier, Soufien [4 ]
Ben Hassine, Thameur [5 ]
Zientara, Stephan [3 ]
Salini, Romolo [1 ]
Hammami, Salah [2 ]
Savini, Giovanni [1 ]
Lorusso, Alessio [1 ]
机构
[1] Ist Zooprofilatt Sperimentale Abruzzo & Molise, I-64100 Campo Boario, Teramo, Italy
[2] Univ Manouba, IRESA, Ecole Natl Med Vet Sidi Thabet, Serv Microbiol Immunol & Pathol Gen, Tunis 2020, Tunisia
[3] Paris Est Univ, Lab Anim Hlth, ANSES, UMR Virol 1161,INRA,ENVA, F-94701 Maisons Alfort, France
[4] Inst Rech Vet Tunisie, Tunis 1006, Tunisia
[5] Commissariat Reg Dev Agr Nbeul, Direct Gen Serv Vet, Nabeul 8000, Tunisia
关键词
Ehdv-8; Experimental infection; Kinetics; Cattle; Sheep; Goats; BLUETONGUE; DEER; CALVES; EPIDEMIOLOGY; OUTBREAK;
D O I
10.12834/VetIt.3433.23112.1
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Epizootic hemorrhagic disease virus serotype 8 (EHDV-8) emerged in Europe for the first time in late 2022. In this study, we investigated the kinetics of EHDV-8 infection in cattle, sheep, and goats. Following experimental infection with EHDV-8, three out of five calves displayed fever, and one calf exhibited ulcerative and crusty lesions of the muzzle. RNAemia peaked at day 7 post infection in all calves and remained relatively stable till the end of the study, at 78 days post infection. Infectious virus was isolated up to 21 days post infection in one calf. As far as small ruminants are concerned, one sheep experienced fever and two out of five had consistent RNAemia that lasted until the end of the study. Remarkably, infectious virus was evidenced at day 7 post infection in one sheep. In goats, no RNA was observed in blood samples. All infected animals seroconverted, and a neutralizing immune response was observed in all species, with calves exhibiting a more robust response than sheep and goats. Our study provides insights into the kinetics of EHDV-8 infection and the host immune responses. We also highlight that sheep may also play a role in EHDV-8 epidemiology. Altogether, the data gathered in this study could have important implications for disease control and prevention strategies, providing crucial information to policy makers to mitigate the impact of this viral disease on livestock.
引用
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页数:11
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