The purpose of this study is to examine the effects of a Chemistry I class based on an artificial intelligence (AI) classification model. To achieve this, the research investigated the development and application of a class utilizing an AI classification model in Chemistry I classes conducted at D High School in Gyeongbuk during the first semester of 2023. After selecting the curriculum content and AI tools, and determining the curriculum-AI integration education model as well as AI hardware and software, we developed detailed activities for the program and applied them in actual classes. Following the implementation of the classes, it was confirmed that students' self-efficacy improved in three aspects: chemistry concept formation, AI value perception, and AI-based maker competency. Specifically, the chemistry classes based on text and image classification models had a positive impact on students' self-efficacy for chemistry concept formation, enhanced students' perception of AI value and interest, and contributed to improving students' AI and physical computing abilities. These results demonstrate the positive impact of the Chemistry I class based on an AI classification model on students, providing evidence of its utility in educational settings.