An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells

被引：1
|
作者：
Zhou, Feng
Yang, Guimei
Liu, Yajing
Xue, Liting
Chen, Weijie
Li, Zhengtao
Liu, Xiaowu
Li, Jian
Tang, Renhong
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-661
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
661
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Cutting edge:: Regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination
    Zhang, J
    Bárdos, T
    Li, DD
    Gál, I
    Vermes, C
    Xu, JY
    Mikecz, K
    Finnegan, A
    Lipkowitz, S
    Glant, TT
    JOURNAL OF IMMUNOLOGY, 2002, 169 (05): : 2236 - 2240
  • [32] THE CBL-B INHIBITOR, NX-0255, ENHANCES HUMAN DRUG ENHANCED TUMOR INFILTRATING LYMPHOCYTE (DETIL) EXPANSION AND T CELL FUNCTION IN FULLSCALE RUNS
    Liang, Xiaoyan
    Wu, Xianzhu
    Jeevan, Jeevitha
    Butler, Samuel
    Murthy, Pranav
    Sands, Arthur
    Lotze, Michael
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A269 - A269
  • [33] GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
    Michelle J. Cox
    Claudia Manriquez Roman
    Erin E. Tapper
    Elizabeth L. Siegler
    Dale Chappell
    Cameron Durrant
    Omar Ahmed
    Sutapa Sinha
    Raphael Mwangi
    Nancy S. Scott
    Mehrdad Hefazi
    Kendall J. Schick
    Paulina Horvei
    Michael W. Ruff
    Ismail Can
    Mohamad Adada
    Evandro Bezerra
    Lionel Aurelien Kankeu Fonkoua
    Sameer A. Parikh
    Neil E. Kay
    Reona Sakemura
    Saad S. Kenderian
    Leukemia, 2022, 36 : 1635 - 1645
  • [34] GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
    Cox, Michelle J.
    Roman, Claudia Manriquez
    Tapper, Erin E.
    Siegler, Elizabeth L.
    Chappell, Dale
    Durrant, Cameron
    Ahmed, Omar
    Sinha, Sutapa
    Mwangi, Raphael
    Scott, Nancy S.
    Hefazi, Mehrdad
    Schick, Kendall J.
    Horvei, Paulina
    Ruff, Michael W.
    Can, Ismail
    Adada, Mohamad
    Bezerra, Evandro
    Fonkoua, Lionel Aurelien Kankeu
    Parikh, Sameer A.
    Kay, Neil E.
    Sakemura, Reona
    Kenderian, Saad S.
    LEUKEMIA, 2022, 36 (06) : 1635 - 1645
  • [35] Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity
    Kennedy, Paul T.
    Saulters, Emma L.
    Duckworth, Andrew D.
    Lim, Yeong Jer
    Woolley, John F.
    Slupsky, Joseph R.
    Cragg, Mark S.
    Ward, Frank J.
    Dahal, Lekh N.
    MOLECULAR THERAPY, 2024, 32 (02) : 457 - 468
  • [36] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration
    Sho Kawaguchi
    Kenta Kawahara
    Yukio Fujiwara
    Koji Ohnishi
    Cheng Pan
    Hiromu Yano
    Akiyuki Hirosue
    Masashi Nagata
    Masatoshi Hirayama
    Junki Sakata
    Hikaru Nakashima
    Hidetaka Arita
    Keisuke Yamana
    Shunsuke Gohara
    Yuka Nagao
    Manabu Maeshiro
    Asuka Iwamoto
    Mayumi Hirayama
    Ryoji Yoshida
    Yoshihiro Komohara
    Hideki Nakayama
    Cancer Immunology, Immunotherapy, 2022, 71 : 2127 - 2139
  • [37] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration
    Kawaguchi, Sho
    Kawahara, Kenta
    Fujiwara, Yukio
    Ohnishi, Koji
    Pan, Cheng
    Yano, Hiromu
    Hirosue, Akiyuki
    Nagata, Masashi
    Hirayama, Masatoshi
    Sakata, Junki
    Nakashima, Hikaru
    Arita, Hidetaka
    Yamana, Keisuke
    Gohara, Shunsuke
    Nagao, Yuka
    Maeshiro, Manabu
    Iwamoto, Asuka
    Hirayama, Mayumi
    Yoshida, Ryoji
    Komohara, Yoshihiro
    Nakayama, Hideki
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (09) : 2127 - 2139
  • [38] Cbl-b inhibited CD4+T cell activation by regulating the expression of miR-99a/miR-125b
    Wu, Mengyun
    Gao, Xiu
    Tang, Yuxu
    Wu, Wenyan
    Zhou, Ji
    Shao, Yu
    Hao, Chuangli
    Yang, Yi
    Zhang, Jinping
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 115
  • [39] Identification of the selective CBL-b inhibitors which effectively prevent T cells from exhaustion and demonstrate synergistic anti-tumor activity in combination with an anti-PD1 antibody
    Zhou, Feng
    Li, Zhengtao
    Liu, Yajing
    Yang, Guimei
    Mai, Wansun
    Yang, Wenqing
    Xue, Liting
    Chen, Ping
    Tang, Renhong
    CANCER RESEARCH, 2023, 83 (07)
  • [40] Novel Bi-Specific Immuno-Modulatory Tribodies Potentiate T Cell Activation and Increase Anti-Tumor Efficacy
    Passariello, Margherita
    Yoshioka, Asami
    Takahashi, Kota
    Hashimoto, Shu-ichi
    Lembo, Rosa Rapuano
    Manna, Lorenzo
    Nakamura, Koji
    De Lorenzo, Claudia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (07)
12345