Bone and Extracellular Signal-Related Kinase 5 (ERK5)

被引：0
|
作者：
Wen, Lei [1 ,2 ,3 ]
Liu, Zirui [1 ,2 ]
Zhou, Libo [1 ,2 ]
Liu, Zhongcheng [1 ,2 ]
Li, Qingda [1 ,2 ]
Geng, Bin [1 ,2 ]
Xia, Yayi [1 ,2 ]
机构：
[1] Lanzhou Univ, Hosp & Clin Med Sch 2, Dept Orthoped, Lanzhou 730030, Peoples R China
[2] Orthoped Clin Med Res Ctr, Intelligent Orthoped Ind Technol Ctr Gansu Prov, Orthoped Clin Med Res Ctr Gansu Prov, Intelligent Orthoped Ind Technol Ctr Gansu Prov,De, Lanzhou 730030, Peoples R China
[3] Yunnan Univ, Dept Orthoped & Trauma Surg, Affiliated Hosp, Kunming 650032, Peoples R China
来源：
BIOMOLECULES | 2024年 / 14卷 / 05期
基金：
中国国家自然科学基金;
关键词：
bone; homeostasis; ERK5; cancer; ACTIVATED PROTEIN-KINASE; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER CELL-PROLIFERATION; SUPPRESSES TUMOR-GROWTH; REGULATED KINASE-5; BREAST-CANCER; TARGETED DELETION; PROSTATE-CANCER; INDUCED APOPTOSIS; PATHWAY;
D O I：
10.3390/biom14050556
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5's significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.
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页数：24
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