A systematic review of allometric scaling exponents for IgG mAbs

被引：0

作者：

Rowland, Simon Peter ^{[1
]}

Nixon, Emma ^{[2
]}

Mohan, Krithika ^{[3
]}

Wang, Qianwen ^{[4
]}

Yates, James W. T. ^{[2
]}

机构：

[1] Haleon, Bldg 5,First Floor, Weybridge KT13 0NY, Surrey, England

[2] GSK, DMPK Modelling, Stevenage, England

[3] DMPK Modelling, 1000 Winter St, Waltham, MA USA

[4] GSK, CPMS Infect Dis & Vaccine, London, England

来源：

XENOBIOTICA | 2024年 / 54卷 / 09期

关键词：

pharmacokinetics; allometric scaling; modelling mAb PK; cynomolgus monkey; mAb global scaling exponents; THERAPEUTIC MONOCLONAL-ANTIBODIES; HUMAN PHARMACOKINETICS; PREDICTION;

D O I：

10.1080/00498254.2024.2383925

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increasing complexity of mAbs in development creates challenges in predicting human pharmacokinetic (PK) parameters from preclinical data. The aim of this analysis was to identify optimal allometric scaling exponents.Data were extracted from literature to create a central database (currently the largest available published database) of two-compartment model parameters for mAbs (n = 59) in cynomolgus monkey (CM) and human.Global allometric exponents were calculated and drug-dependent factors were investigated as potential variables in determining the optimal scaling factor.The global exponents for scaling CM mAb PK data were 0.74 (CL), 0.80 (CL with Fc-modified mAbs excluded), 0.44 (CL with Fc-modified mAbs only), 0.71 (Q), 1.12 (V1), and 0.99 (V2). These values are in line with previously published literature values.

引用

页码：609 / 614

页数：6

共 50 条

[31] Allometric scaling in-vitro
Ahluwalia, Arti
SCIENTIFIC REPORTS, 2017, 7
[32] Obesity and Allometric Scaling of Pharmacokinetics
Douglas J. Eleveld
Johannes H. Proost
Anthony R. Absalom
Michel M. R. F. Struys
Clinical Pharmacokinetics, 2011, 50 : 751 - 753
[33] Allometric scaling in-vitro
Arti Ahluwalia
Scientific Reports, 7
[34] Analytic theories of allometric scaling
Agutter, Paul S.
Tuszynski, Jack A.
JOURNAL OF EXPERIMENTAL BIOLOGY, 2011, 214 (07): : 1055 - 1062
[35] Allometric scaling laws of metabolism
da Silva, Jafferson Kamphorst Leal
Garcia, Guilherme J. M.
Barbosa, Lauro A.
PHYSICS OF LIFE REVIEWS, 2006, 3 (04) : 229 - 261
[36] Allometric scaling of mammalian metabolism
White, CR
Seymour, RS
JOURNAL OF EXPERIMENTAL BIOLOGY, 2005, 208 (09): : 1611 - 1619
[37] Relating Lagrangian passive scalar scaling exponents to Eulerian scaling exponents in turbulence
Schmitt, FG
EUROPEAN PHYSICAL JOURNAL B, 2005, 48 (01): : 129 - 137
[38] Relating Lagrangian passive scalar scaling exponents to Eulerian scaling exponents in turbulence
F. G. Schmitt
The European Physical Journal B - Condensed Matter and Complex Systems, 2005, 48 : 129 - 137
[39] Interspecies Pharmacokinetics. 1. Allometric Scaling of Pharmacokinetic Parameters (a Review)
O. V. Polekhina
N. V. Obraztsov
V. A. Petrunin
T. A. Vysotskaya
Pharmaceutical Chemistry Journal, 2014, 48 : 421 - 429
[40] Interspecies Pharmacokinetics. 1. Allometric Scaling of Pharmacokinetic Parameters (a Review)
Polekhina, O. V.
Obraztsov, N. V.
Petrunin, V. A.
Vysotskaya, T. A.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (07) : 421 - 429

← 1 2 3 4 5 →