Effects of esketamine and fluoxetine on depression-like behaviors in chronic variable stress: a role of plasma inflammatory factors

被引:1
|
作者
Chen, Haixia [1 ]
Zhao, Xinxin [2 ]
Ma, Xinxu [3 ]
Ma, Hongzhe [3 ]
Zhou, Cuihong [3 ]
Zhang, Yunyun [2 ]
Peng, Zhengwu [3 ]
Xue, Shanshan [3 ]
Cai, Min [1 ,3 ]
机构
[1] Northwest Univ, Coll Life Sci & Med, Xian, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Xian, Shaanxi, Peoples R China
[3] Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Shaanxi, Peoples R China
来源
FRONTIERS IN PSYCHIATRY | 2024年 / 15卷
基金
中国国家自然科学基金;
关键词
esketamine; fluoxetine; major depressive disorder; chronic variable stress; inflammatory cytokines; CHEMOKINE RECEPTORS; PERIPHERAL CYTOKINE; MAJOR DEPRESSION; METAANALYSIS; KETAMINE; IMPAIRMENT; INSIGHTS; PROTEIN; ALPHA; IL-6;
D O I
10.3389/fpsyt.2024.1388946
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Mounting evidence has identified the rapid and sustained antidepressive and anxiolytic-like effects of esketamine. However, the underlying mechanism of this no-monoamine target rapid-onset antidepressant is still underexplored. Immune-inflammatory pathways and cell-mediated immune activation, mainly including inflammatory cytokines in plasma, play a pivotal role in the pathogenesis of major depressive disorder and are also a potential therapeutic target for MDD. The current study was designed to clarify the role of esketamine on the expression of plasma cytokines in a depressive-like model introduced by chronic variable stress (CVS). In this study, a 21-day consecutive CVS protocol was applied to produce depressive- and anxiety-like behaviors. After the single dose or 7-day repeated administration of esketamine or fluoxetine, the depressive- and anxiety-like behaviors and the expression of inflammatory cytokines in plasma were examined. Both a single dose of esketamine and 7-days repeated fluoxetine administration elicited anti-depressive and anxiolytic effects in mice exposed to CVS. Additionally, CVS produced significant changes in the plasma inflammatory factors, notably increasing the expression of IL-1 beta, IL-6, IL-8, IL-17A, TNF alpha, IL-4, IL-9, IL-24, IL-37, IFN-beta, and CXCL12, while reducing IL-10 and IL-33. With the administration of esketamine and fluoxetine, CVS-produced inflammatory disturbances were partially normalized. Together, our findings provide a novel insight that acute esketamine treatment could rescue CVS-produced depressive-like and anxiety-like behaviors in mice by normalizing the expression of inflammatory cytokines; this effect was similar to the repeated administration of fluoxetine. These results contributed to the understating of rapid anti-depressant effects elicited by esketamine.
引用
收藏
页数:11
相关论文
共 50 条
  • [41] Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress
    Li Jianguo
    Jia Xueyang
    Wang Cui
    Wu Changxin
    Qin Xuemei
    Translational Psychiatry, 9
  • [42] Chronic stress induce prolonged depression-like behavior in mice
    Hashikawa, Narumi
    Sakamoto, Yusuke
    Sawada, Ayaka
    Sasaki, Hitomi
    Hamamoto, Hikari
    Ochiai, Youko
    Hashikawa, Naoya
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121 : 185P - 185P
  • [43] Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
    Joo, Yeon
    Choi, Kyung Mi
    Lee, Young Hyurk
    Kim, Gyeongwha
    Lee, Dong Hoon
    Roh, Gu Seob
    Kang, Sang Soo
    Cho, Gyeong Jae
    Choi, Wan Sung
    Kim, Hyun Joon
    NEUROSCIENCE LETTERS, 2009, 461 (02) : 121 - 125
  • [44] Whole body vibration training improves depression-like behaviors in a rat chronic restraint stress model
    Peng, Guangcong
    Yang, Luodan
    Wu, Chong Y.
    Zhang, Ling L.
    Wu, Chun Y.
    Li, Fan
    Shi, Hai W.
    Hou, Jun
    Zhang, Li M.
    Ma, Xu
    Xiong, Jing
    Pan, Hongying
    Zhang, Guang Q.
    NEUROCHEMISTRY INTERNATIONAL, 2021, 142
  • [45] Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota
    Song, Xujiao
    Wang, Weihao
    Ding, Shanshan
    Liu, Xingyue
    Wang, Yan
    Ma, Hao
    JOURNAL OF AFFECTIVE DISORDERS, 2021, 290 : 353 - 363
  • [46] Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats
    Nassar, Ahmad
    Azab, Abed N.
    PHARMACEUTICALS, 2022, 15 (09)
  • [47] Silibinin prevents depression-like behaviors in a single prolonged stress rat model: the possible role of serotonin
    Lee, Bombi
    Choi, Gwang Muk
    Sur, Bongjun
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2020, 20 (01) : 70
  • [48] Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats
    Nabirumbi, Ritah
    Onohuean, Hope
    Drago, Kato Charles
    Alagbonsi, Abdullateef Isiaka
    Adedeji, Ahmed A.
    SCIENCE PROGRESS, 2024, 107 (01)
  • [49] Role of the Suprachiasmatic Nucleus in the Regulation of Anxiety and Depression-Like Behaviors in Mice
    Vadnie, Chelsea
    Eberhardt, Lauren
    Hildebrand, Mariah
    Zhang, Hui
    Logan, Ryan
    Becker-Krail, Darius
    McClung, Colleen
    NEUROPSYCHOPHARMACOLOGY, 2019, 44 (SUPPL 1) : 85 - 86
  • [50] Silibinin prevents depression-like behaviors in a single prolonged stress rat model: the possible role of serotonin
    Bombi Lee
    Gwang Muk Choi
    Bongjun Sur
    BMC Complementary Medicine and Therapies, 20