Retrograde endocannabinoid signaling at inhibitory synapses in vivo

被引：6

作者：

Dudok, Barna ^{[1
,2
,3
]}

Fan, Linlin Z. ^{[4
]}

Farrell, Jordan S. ^{[3
,5
,6
,7
]}

Malhotra, Shreya ^{[3
]}

Homidan, Jesslyn ^{[3
]}

Kim, Doo Kyung ^{[4
]}

Wenardy, Celestine ^{[4
]}

Ramakrishnan, Charu ^{[8
]}

Li, Yulong ^{[9
]}

Deisseroth, Karl ^{[4
,10
,11
]}

Soltesz, Ivan ^{[3
]}

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[3] Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[5] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[6] Boston Childrens Hosp, Rosamund Stone Zander Translat Neurosci Ctr, Boston, MA 02115 USA

[7] Harvard Med Sch, Dept Neurol, Boston Childrens Hosp, Boston, MA 02115 USA

[8] Stanford Univ, Cracking Neural Code CNC Program, Stanford, CA 94305 USA

[9] Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China

[10] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[11] Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

SCIENCE | 2024年 / 383卷 / 6686期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

HIPPOCAMPAL PLACE CELLS; ENDOGENOUS CANNABINOIDS; GABA; CB1; OSCILLATIONS; RESOLUTION; RECEPTORS; DYNAMICS; RELEASE; LIPASE;

D O I：

10.1126/science.adk3863

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocannabinoid (eCB)-mediated suppression of inhibitory synapses has been hypothesized, but this has not yet been demonstrated to occur in vivo because of the difficulty in tracking eCB dynamics and synaptic plasticity during behavior. In mice navigating a linear track, we observed location-specific eCB signaling in hippocampal CA1 place cells, and this was detected both in the postsynaptic membrane and the presynaptic inhibitory axons. All-optical in vivo investigation of synaptic responses revealed that postsynaptic depolarization was followed by a suppression of inhibitory synaptic potentials. Furthermore, interneuron-specific cannabinoid receptor deletion altered place cell tuning. Therefore, rapid, postsynaptic, activity-dependent eCB signaling modulates inhibitory synapses on a timescale of seconds during behavior.

引用

页码：967 / 970

页数：4

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