Supplemental Oxygen and Acute Myocardial Infarction ― A Systematic Review and Meta-Analysis ―

被引:4
|
作者
Kojima, Sunao [1 ]
Yamamoto, Takeshi [2 ]
Kikuchi, Migaku [3 ]
Hanada, Hiroyuki [4 ]
Mano, Toshiaki [5 ]
Nakashima, Takahiro [6 ,7 ]
Hashiba, Katsutaka [8 ]
Tanaka, Akihito [9 ]
Yamaguchi, Junichi [10 ]
Matsuo, Kunihiro [11 ]
Nakayama, Naoki [12 ]
Nomura, Osamu [4 ]
Matoba, Tetsuya [13 ]
Tahara, Yoshio [14 ]
Nonogi, Hiroshi [15 ]
机构
[1] Sakurajyuji Yatsushiro Rehabil Hosp, Dept Internal Med, Yatsushiro, Japan
[2] Nippon Med Coll Hosp, Div Cardiovasc Intens Care, Tokyo, Japan
[3] Dokkyo Med Univ, Emergency & Crit Care Ctr, Dept Cardiovasc Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan
[4] Hirosaki Univ, Dept Emergency & Disaster Med, Hirosaki, Japan
[5] Kansai Rosai Hosp, Cardiovasc Ctr, Amagasaki, Japan
[6] Univ Michigan, Dept Emergency Med, Ann Arbor, MI USA
[7] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI USA
[8] Saiseikai Yokohama shi Nanbu Hosp, Dept Cardiol, Yokohama, Japan
[9] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Japan
[10] Tokyo Womens Med Univ, Dept Cardiol, Tokyo, Japan
[11] Fukuoka Univ, Chikushi Hosp, Dept Acute Care Med, Fukuoka, Japan
[12] Kanagawa Cardiovasc & Resp Ctr, Dept Cardiol, Yokohama, Japan
[13] Kyushu Univ, Fac Med Sci, Dept Cardiovasc Med, Fukuoka, Japan
[14] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, Osaka, Japan
[15] Osaka Aoyama Univ, Fac Hlth Sci, Osaka, Japan
关键词
Acute coronary syndrome; Acute myocardial infarction; Ambient air; Oxygen; ST-elevation myocardial infarction; THERAPY;
D O I
10.1253/circrep.CR-22-0031
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: In Japan, oxygen is commonly administered during the acute phase of myocardial infarction (MI) to patients without oxygen saturation monitoring. In this study we assessed the effects of supplemental oxygen therapy, compared with ambient air, on mortality and cardiac events by synthesizing evidence from randomized controlled trials (RCTs) of patients with suspected or confirmed acute MI. Methods and Results: PubMed was systematically searched for full-text RCTs published in English before June 21, 2020. Two reviewers independently screened the search results and appraised the risk of bias. The estimates for each outcome were pooled using a random-effects model. In all, 2,086 studies retrieved from PubMed were screened. Finally, 7,322 patients from 9 studies derived from 4 RCTs were analyzed. In-hospital mortality in the oxygen and ambient air groups was 1.8% and 1.6%, respectively (risk ratio [RR] 0.90; 95% confidence interval [CI] 0.38-2.10]); 0.8% and 0.5% of patients, respectively, experienced recurrent MI (RR 0.44; 95% CI 0.12-1.54), 1.5% and 1.6% of patients, respectively, experienced cardiac shock (RR 1.10; 95% CI 0.77-1.59]), and 2.4% and 2.0% of patients, respectively, experienced cardiac arrest (RR 0.91; 95% CI 0.43-1.94). Conclusions: Routine supplemental oxygen administration may not be beneficial or harmful, and high-flow oxygen may be unnecessary in normoxic patients in the acute phase of MI.
引用
收藏
页码:335 / 344
页数:10
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