Synthesis of Novel Sulfonamide Derivatives Featuring 1-(Methylsulfonyl)-4-(2,3,4-Trimethoxybenzyl)Piperazine Core Structures

被引：0
|
作者：
Ivanov, Iliyan [1 ]
Manolov, Stanimir [1 ]
Bojilov, Dimitar [1 ]
Dimitrova, Diyana [1 ]
Nedialkov, Paraskev [2 ]
机构：
[1] Paisij Hilendarski Univ Plovdiv, Fac Chem, Dept Organ Chem, 24 Tsar Assen Str, Plovdiv 4000, Bulgaria
[2] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, 2 Dunav Str, Sofia 1000, Bulgaria
来源：
MOLBANK | 2024年 / 2024卷 / 03期
关键词：
trimetazidine; 1-(2,3,4-trimethoxybenzyl)piperazine; sulfonamides; methanesulfonyl chloride; benzenesulfonyl chloride; phenylmethanesulfonyl chloride; angina pectoris; doping; TRIMETAZIDINE; DRUGS;
D O I：
10.3390/M1879
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report the synthesis of three novel sulfonamide derivatives of trimetazidine-medication primarily used to treat angina pectoris. The new compounds have been fully characterized with their melting point, 1H- and 13C-NMR, UV, and mass spectrometry. The collected data confirm the successful synthesis and structural integrity of the new molecules.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] BENZYLPIPERAZINE DERIVATIVES .1. SYNTHESES AND BIOLOGICAL-ACTIVITIES OF 1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DERIVATIVES
    OHTAKA, H
    MIYAKE, M
    KANAZAWA, T
    ITO, K
    TSUKAMOTO, G
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1987, 35 (07) : 2774 - 2781
  • [2] BENZYLPIPERAZINE DERIVATIVES .11. SYNTHESIS OF COMPOUNDS RELATED TO THE METABOLITES OF 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE (KB-2796)
    OHTAKA, H
    HORI, M
    IEMURA, R
    YUMIOKA, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1989, 37 (11) : 3122 - 3124
  • [3] Synthesis of N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine Organic Salts and their Cardiotropic Activity
    G. V. Mokrov
    S. I. Bobrovskii
    V. V. Barchukov
    S. A. Kryzhanovskii
    I. B. Tsorin
    M. B. Vititnova
    A. G. Rebeko
    T. A. Gudasheva
    Pharmaceutical Chemistry Journal, 2022, 56 : 1049 - 1053
  • [4] Synthesis of N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine Organic Salts and their Cardiotropic Activity
    Mokrov, G., V
    Bobrovskii, S., I
    Barchukov, V. V.
    Kryzhanovskii, S. A.
    Tsorin, I. B.
    Vititnova, M. B.
    Rebeko, A. G.
    Gudasheva, T. A.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (08) : 1049 - 1053
  • [5] ISOLATION AND IDENTIFICATION OF THE NEW METABOLITES OF 1-[BIS(4-FLUOROPHENYL)-METHYL]-4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE (KB-2796) FROM RAT BILE, URINE AND FECES
    KAWASHIMA, T
    SATOMI, O
    AWATA, N
    JOURNAL OF PHARMACOBIO-DYNAMICS, 1991, 14 (08): : 449 - 459
  • [6] Synthesis and Na+/H+ Exchanger-1-Inhibitory Activity of 4(6)-{2-[4-(2,3,4-Trimethoxybenzyl)piperazin-1-yl]-2-oxoethoxy}aroylguanidine Derivatives
    Jin, Lu
    Jiang, Xiangmin
    He, Guangwei
    Xu, Wenting
    Gong, Guoqing
    Xu, Yungen
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 32 (02) : 326 - 332
  • [7] Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators
    Li, Ridong
    Ning, Xianling
    He, Jianan
    Lin, Zhiqiang
    Su, Yue
    Li, Runtao
    Yin, Yuxin
    BIOORGANIC CHEMISTRY, 2021, 108
  • [8] CARDIOVASCULAR EFFECTS OF N-(2,3,4 TRIMETHOXYBENZYL)-PIPERAZINE HC1 (USVP-D177)
    MIRSKY, JH
    GLASSMAN, JM
    SOUTHERLAND, T
    JAHNDHYA.B
    PHARMACOLOGIST, 1969, 11 (02): : 270 - +
  • [9] Pharmacological Preconditioning of Mesenchymal Stem Cells with Trimetazidine (1-[2,3,4-Trimethoxybenzyl]piperazine) Protects Hypoxic Cells against Oxidative Stress and Enhances Recovery of Myocardial Function in Infarcted Heart through Bcl-2 Expression
    Wisel, Sheik
    Khan, Mahmood
    Kuppusamy, M. Lakshmi
    Mohan, I. Krishna
    Chacko, Simi M.
    Rivera, Brian K.
    Sun, Benjamin C.
    Hideg, Kalman
    Kuppusamy, Periannan
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 329 (02): : 543 - 550
  • [10] Novel 1-(2-Methoxyphenyl)-4-[3-Aryloxy-2-Hydroxypropyl]-Piperazine Derivatives and Their Block Effects on α1-Adrenoceptor Subtypes
    Huang, Junjun
    Zhu, Liu
    Huang, Yajian
    Yuan, Mu
    LATIN AMERICAN JOURNAL OF PHARMACY, 2014, 33 (02): : 273 - 277
12345