Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19

被引：3

作者：

Souza-Silva, Nathalia Gualberto ^{[1
]}

Rosa, Daniela Valadao ^{[1
]}

de Paula, Jonas Jardim ^{[1
,3
]}

Coimbra, Roney Santos ^{[4
]}

Miranda, Debora Marques ^{[1
,2
]}

Romano-Silva, Marco Aurelio ^{[1
,3
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Ctr Tecnol Med Mol CTMM, Ave Alfredo Balena 190, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais UFMG, Dept Pediat, Fac Med, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais UFMG, Dept Psiquiatria, Fac Med, Ave Alfredo Balena 190,Sala 114, BR-30130100 Belo Horizonte, MG, Brazil

[4] Fiocruz MS, Inst Rene Rachou, Neurogen Imunopatol, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2024年 / 389卷

关键词：

Post-acute COVID-19 syndrome; Neuroinflammation; Cytokine; Cognitive symptoms; Visuospatial processing; NEUROINFLAMMATION;

D O I：

10.1016/j.jneuroim.2024.578327

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Individuals who experience mild COVID-19 can suffer from long-lasting cognitive symptoms. Notably, 26% of these individuals experience difficulties with visuospatial abilities six months after infection. However, among those who initially exhibited visuoconstructive impairments, 66% showed improvement or complete reversal over time. Additionally, changes in cytokine levels, particularly CCL11, HGF, and CXCL10, were observed. These results suggest a potential link between ongoing cognitive issues and elevated levels of pro-inflammatory cytokines, which merits further investigation.

引用

页数：6

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