Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders

被引:2
|
作者
Yin, Ji-Hang [1 ]
Horzmann, Katharine A. [1 ]
机构
[1] Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA
基金
美国国家卫生研究院;
关键词
apoptosis; early life exposure; environmental pollutants; neurodegenerative disorders; neurotransmission; neurotoxicity; oxidative stress; zebrafish; OXIDATIVE STRESS; DNA METHYLATION; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; PHOTOMOTOR RESPONSE; ADULT ZEBRAFISH; ACUTE TOXICITY; RISK-FACTOR; TRANSCRIPTOME ALTERATIONS; DOPAMINERGIC-NEURONS;
D O I
10.3390/biomedicines12071559
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Environmental pollutants have been linked to neurotoxicity and are proposed to contribute to neurodegenerative disorders. The zebrafish model provides a high-throughput platform for large-scale chemical screening and toxicity assessment and is widely accepted as an important animal model for the investigation of neurodegenerative disorders. Although recent studies explore the roles of environmental pollutants in neurodegenerative disorders in zebrafish models, current knowledge of the mechanisms of environmentally induced neurodegenerative disorders is relatively complex and overlapping. This review primarily discusses utilizing embryonic zebrafish as the model to investigate environmental pollutants-related neurodegenerative disease. We also review current applicable approaches and important biomarkers to unravel the underlying mechanism of environmentally related neurodegenerative disorders. We found embryonic zebrafish to be a powerful tool that provides a platform for evaluating neurotoxicity triggered by environmentally relevant concentrations of neurotoxic compounds. Additionally, using variable approaches to assess neurotoxicity in the embryonic zebrafish allows researchers to have insights into the complex interaction between environmental pollutants and neurodegenerative disorders and, ultimately, an understanding of the underlying mechanisms related to environmental toxicants.
引用
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页数:29
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