AI-guided generation of novel GUCY2C-targeting T-cell engagers for the treatment of colorectal cancer

被引:0
|
作者
Tian, Liang
Hou, Jinxiu
Su, Chenpeng
Xu, Xiaoou
Chen, Xiaoqian
Liu, Dandan
Tian, Jiyuan
Shen, Rui
Pan, Yi
Yuan, Yuan
Dong, Lisha
Gu, Tingting
Peng, Jian
机构
关键词
D O I
10.1158/1538-7445.AM2024-6721
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6721
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Generation of ImmTACTM molecules: Engineering high-affinity soluble T-cell receptors for the treatment of cancer
    Bombik, Izabela
    Bortoluzzi, Alessio
    Mai, Nicole
    Preston, Andrew
    Vuidepot, Annelise
    Jakobsen, Bent K.
    Liddy, Nathaniel
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (02)
  • [42] Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer
    Abraham, Adedoyin D.
    Esquer, Hector
    Zhou, Qiong
    Tomlinson, Nicholas
    Hamill, Brayden D.
    Abbott, Joshua M.
    Li, Linfeng
    Pike, Laura A.
    Rinaldetti, Sebastien
    Ramirez, Dominique A.
    Lunghofer, Paul J.
    Gomez, Jose D.
    Schaack, Jerome
    Nemkov, Travis
    D'Alessandro, Angelo
    Hansen, Kirk C.
    Gustafson, Daniel L.
    Messersmith, Wells A.
    LaBarbera, Daniel V.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (22) : 10182 - 10203
  • [43] T-cell redirected killing and cure of pancreatic and gastric cancer xenografts by targeting Trop-2.
    Goldenberg, David M.
    Rossi, Edmund A.
    Rossi, Diane L.
    Cardillo, Thomas M.
    Chang, Chien-Hsing
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (03)
  • [44] Overcoming T cell exhaustion by targeting tumor suppressor p53 isoforms as a novel approach to improve T-cell based cancer immunotherapy
    Legscha, K. J.
    Atunes, E.
    Amann, E.
    Theobald, M.
    Echchannaoui, H.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 205 - 205
  • [45] Rapid Generation of Murine Bispecific Antibodies Using FAST-Ig™ for Preclinical Screening of HER2/CD3 T-Cell Engagers
    Koga, Hikaru
    Kuroi, Haruka
    Hirano, Rena
    Hirayama, Hiroyuki
    Nabuchi, Yoshiaki
    Kuramochi, Taichi
    ANTIBODIES, 2024, 13 (01)
  • [46] Forimtamig, a novel GPRC5D-targeting T-cell bispecific antibody with a 2+1 format, for the treatment of multiple myeloma
    Eckmann, Jan
    Fauti, Tanja
    Biehl, Marlene
    Zabaleta, Aintzane
    Blanco, Laura
    Lelios, Iva
    Gottwald, Stefan
    Rae, Richard
    Lechner, Stefanie
    Bayer, Christa
    Dekempe, Quincy
    Osl, Franz
    Carrie, Nadege
    Kassem, Sahar
    Lorenz, Stefan
    Christopeit, Tony
    Carpy, Alejandro
    Bujotzek, Alexander
    Broeske, Ann-Marie
    Dekhtiarenko, Iryna
    Attig, Jan
    Kunz, Leo
    Cremasco, Floriana
    Adelfio, Roberto
    Fertig, Georg
    Dengl, Stefan
    Gassner, Christian
    Bormann, Felix
    Kirstenpfad, Claudia
    Kraft, Thomas
    Diggelmann, Sarah
    Knobloch, Melanie
    Hage, Carina
    Feddersen, Romi
    Heidkamp, Gordon
    Poeschinger, Thomas
    Mayoux, Maud
    Bernasconi, Luise
    Prosper, Felipe
    Dumontet, Charles
    Martinet, Ludovic
    Leclair, Stephane
    Xu, Wei
    Paiva, Bruno
    Klein, Christian
    Umana, Pablo
    BLOOD, 2025, 145 (02) : 202 - 219
  • [47] Generation of Tumor-Specific Cytotoxic T-Lymphocytes from the Peripheral Blood of Colorectal Cancer Patients for Adoptive T-Cell Transfer
    Carluccio, Silvia
    Delbue, Serena
    Signorini, Lucia
    Setola, Elisabetta
    Bagliani, Anna
    Della Valle, Alberto
    Galli, Andrea
    Ferrante, Pasquale
    Bregni, Marco
    JOURNAL OF CELLULAR PHYSIOLOGY, 2015, 230 (07) : 1457 - 1465
  • [48] GENERATION OF TUMOR-SPECIFIC CYTOTOXIC T-LYMPHOCYTES FROM PERIPHERAL BLOOD FOR ADOPTIVE T-CELL TRANSFER IN COLORECTAL CANCER PATIENTS
    Bregni, M.
    Carluccio, S.
    Del Bue, S.
    Ferrante, P.
    BONE MARROW TRANSPLANTATION, 2014, 49 : S97 - S97
  • [49] GENERATION OF TUMOR-SPECIFIC CYTOTOXIC T-LYMPHOCYTES FROM PERIPHERAL BLOOD OF COLORECTAL CANCER PATIENTS FOR ADOPTIVE T-CELL TRANSFER
    Carluccio, S.
    Delbue, S.
    Signorini, L.
    Dallari, S.
    Elia, F.
    Galli, A.
    Della Valle, A.
    Ferrante, P.
    Bregni, M.
    BONE MARROW TRANSPLANTATION, 2014, 49 : S129 - S129
  • [50] Generation of tumour-specific cytotoxic T-lymphocytes from peripheral blood of colorectal cancer patients for adoptive t-cell transfer
    Corluccio, S.
    Delbue, S.
    Ferrante, P.
    Bregni, M.
    BONE MARROW TRANSPLANTATION, 2013, 48 : S33 - S33