AI-guided generation of novel GUCY2C-targeting T-cell engagers for the treatment of colorectal cancer

被引：0
|
作者：
Tian, Liang
Hou, Jinxiu
Su, Chenpeng
Xu, Xiaoou
Chen, Xiaoqian
Liu, Dandan
Tian, Jiyuan
Shen, Rui
Pan, Yi
Yuan, Yuan
Dong, Lisha
Gu, Tingting
Peng, Jian
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-6721
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6721
引用
收藏
页数：2
相关论文
共 50 条
  • [1] AI-guided tailor-made anti-TROP2 T-cell engagers for T-cell mediated cancer immunotherapy with enhanced therapeutic index
    Chen, Chuan
    Tian, Liang
    Su, Chenpeng
    Liu, Dandan
    Chen, Xiaoqian
    Zhou, Yifei
    Jiang, Suze
    Wang, Guifang
    Tian, Jiyuan
    Yuan, Yuan
    Yang, Bing
    Peng, Jian
    CANCER RESEARCH, 2024, 84 (06)
  • [2] Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer
    Tapia-Galisteo, Antonio
    Sanchez Rodriguez, Inigo
    Aguilar-Sopena, Oscar
    Lykke Harwood, Seandean
    Narbona, Javier
    Ferreras Gutierrez, Mariola
    Navarro, Rocio
    Martin-Garcia, Laura
    Corbacho, Cesareo
    Compte, Marta
    Lacadena, Javier
    Blanco, Francisco J.
    Chames, Patrick
    Roda-Navarro, Pedro
    Alvarez-Vallina, Luis
    Sanz, Laura
    ONCOIMMUNOLOGY, 2022, 11 (01):
  • [3] ENHANCING ANTITUMOR IMMUNITY WITH IMMUNOTHERAPY: A COMBINATION OF NOVEL BISPECIFIC T-CELL ENGAGERS TARGETING COLORECTAL CANCER
    Giampa, R.
    Menotti, M.
    Haas, T.
    De Maria, R.
    HUMAN GENE THERAPY, 2023, 34 (21-22) : A40 - A40
  • [4] Novel GUCY2C targeting CAR-T therapy: Efficacy in advanced colorectal cancer
    Zhang, Qianyu
    Lin, Lin
    Wang, Lin
    Wang, Wei
    Qian, Liting
    Pan, Yueyin
    Liu, Hu
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [5] MAIT engagers: An efficacious novel modality in the field of T-cell engagers for the treatment of solid tumors
    Plyte, Simon Edward
    Fraudeau, Marie
    Grivel, Jonathan
    Hougron, Paloma
    Klausz, Katja
    Winterberg, Dorothee
    von Below, Britta
    Ivagnes, Alexandre
    Germain, Claire
    Amigorena, Sebastian
    Zhukovsky, Eugene
    Peipp, Matthias
    Gerard, Pierre-Emmanuel
    Lantz, Olivier
    Prigent, Julie
    CANCER RESEARCH, 2023, 83 (07)
  • [6] DEVELOPMENT OF GUCY2C-TAC T CELLS FOR THE TREATMENT OF COLORECTAL CANCER
    Benatar, Tania
    Wang, Ling
    Nitya-Nootan, Thanyashanthi
    MacGregor, Heather
    Prosser, Suzanna
    Philbert, I. P.
    Lal, Prabha
    Xu, Stacey
    Shaver, Laura
    Sengupta, Sadhak
    Helsen, Christopher
    Bader, Andreas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A214 - A214
  • [7] A THIRD-GENERATION HUMAN GUCY2C-TARGETED CAR-T CELL FOR COLORECTAL CANCER IMMUNOTHERAPY
    Baybutt, Trevor
    Snook, Adam
    Waldman, Scott
    Stem, Jonathan
    Caparosa, Ellen
    Zalewski, Alicja
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A65 - A66
  • [8] Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer
    Peter A. Szijj
    Melissa A. Gray
    Mikaela K. Ribi
    Calise Bahou
    João C. F. Nogueira
    Carolyn R. Bertozzi
    Vijay Chudasama
    Nature Chemistry, 2023, 15 : 1636 - 1647
  • [9] Combination therapies for the optimisation of Bispecific T-cell Engagers in cancer treatment
    Zhu, Winston M.
    Middleton, Mark R.
    IMMUNOTHERAPY ADVANCES, 2023, 3 (01):
  • [10] Revolutionizing Hematologic Cancer Treatment: The Promise of Bispecific T-Cell Engagers
    Budde, Lihua E.
    Pak, Stacy
    Seipel, Lauren R.
    JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2023, 21 : 2 - 5
12345