Modeling tumor immunoediting under immune selective pressure to inform neoantigen landscape dynamics for effective cancer vaccines

被引：0
|
作者：
George, Mariam Mathew
Lihm, Jayon
Choi, Hyejin
Elhanati, Yuval
Martis, Stephen
Luksza, Marta
Greenbaum, Benjamin
Wolchok, Jedd D.
Merghoub, Taha
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-4093
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4093
引用
收藏
页数：2
相关论文
共 16 条
  • [1] STING in cancer immunoediting: Modeling tumor-immune dynamics throughout cancer development
    Zhang, Xiao
    Chen, Yan
    Liu, Xi
    Li, Guoli
    Zhang, Shuo
    Zhang, Qi
    Cui, Zihan
    Qin, Minglu
    Simon, Hans-Uwe
    Terzic, Janos
    Kocic, Gordana
    Polic, Bojan
    Yin, Chengliang
    Li, Xiaobo
    Zheng, Tongsen
    Liu, Bing
    Zhu, Yuanyuan
    CANCER LETTERS, 2025, 612
  • [2] Unveiling the immunological landscape: comprehensive characterization of neoantigen-reactive immune cells in neoantigen cancer vaccines
    Liu, Weijiang
    Su, Hong
    Guo, Peng
    Hong, Liping
    Hao, Xishan
    Li, Xiaoling
    FRONTIERS IN IMMUNOLOGY, 2025, 16
  • [3] Overlapping and distinct mechanisms of effective neoantigen cancer vaccines and immune checkpoint therapy
    Keshari, Sunita
    Shavkunov, Alexander S.
    Miao, Qi
    Saha, Akata
    Williams, Charmelle D.
    Pineda, Josue E.
    Hu, Kenneth
    Pauken, Kristen E.
    Chen, Ken
    Gubin, Matthew M.
    CANCER RESEARCH, 2024, 84 (06)
  • [4] Analysis of tumor-immune functional responses in a mathematical model of neoantigen cancer vaccines
    Han, Lifeng
    Messan, Marisabel Rodriguez
    Yogurtcu, Osman N.
    Nukala, Ujwani
    Yang, Hong
    MATHEMATICAL BIOSCIENCES, 2023, 356
  • [5] Dynamics of a Mathematical Model of Cancer and Immunoediting Scenarios Under the Variation of the Immune Cell Activation Rate
    Nova Martinez, Manuel Arturo
    Granada Diaz, Hector Andres
    Calderon Saavedra, Pablo Emilio
    INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2022, 32 (06):
  • [6] Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade
    Miller, Peter G.
    Gibson, Christopher J.
    Mehta, Arnav
    Sperling, Adam S.
    Frederick, Dennie T.
    Manos, Michael P.
    Miao, Benchun
    Hacohen, Nir
    Hodi, F. Stephen
    Boland, Genevieve M.
    Ebert, Benjamin L.
    JCO PRECISION ONCOLOGY, 2020, 4 : 1027 - 1033
  • [7] MATHEMATICAL MODELING AND SOLUTION LANDSCAPE REVEAL CANCER PROGRESSION DYNAMICS IN TUMOR ECOLOGICAL MICROENVIRONMENT
    Wang, Shun
    Wang, Tengfei
    Wu, Shuonan
    Zhang, Lei
    Zou, Xiufen
    SIAM JOURNAL ON APPLIED MATHEMATICS, 2025, 85 (01) : 50 - 77
  • [8] Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
    Keshari, Sunita
    Shavkunov, Alexander S.
    Miao, Qi
    Saha, Akata
    Minowa, Tomoyuki
    Molgora, Martina
    Williams, Charmelle D.
    Chaib, Mehdi
    Highsmith, Anna M.
    Pineda, Josue E.
    Alekseev, Sayan
    Alspach, Elise
    Hu, Kenneth H.
    Colonna, Marco
    Pauken, Kristen E.
    Chen, Ken
    Gubin, Matthew M.
    CELL REPORTS, 2024, 43 (11):
  • [9] Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity
    Zhang, Zhe
    Xia, Yimeng
    Wang, Zhihong
    Sun, Yaxing
    Pu, Dan
    He, Yijia
    Liu, Ruixian
    Zhang, Yanru
    Liu, Yan
    Yu, Junzhi
    Ning, Shiyang
    Feng, Baisui
    Wang, Yaohe
    Wang, Na
    FRONTIERS IN IMMUNOLOGY, 2025, 16
  • [10] Computational Modeling of Tumor Dynamics Incorporating Drug Resistance and Immune Response for Optimized Cancer Treatment
    Francis Oketch Ochieng
    International Journal of Applied and Computational Mathematics, 2025, 11 (2)
12