A Fully Integrated Conformal Wearable Ultrasound Patch for Continuous Sonodynamic Therapy

Cancer treatment is a continuous process, that the current therapy cannot meet the requirement well, including radiotherapy and chemotherapy. Wearable ultrasound device has the potential for continuous sonodynamic therapy due to its portability. However, the miniaturization of ultrasonic probe, system integration of device, and the strategy of continuous treatment are still urgent issues to be addressed. Herein, a portable wearable antitumor system is introduced, which utilizes a custom-developed multiplexed ultrasonic patch array (CWUS Patch) to accurately focus ultrasound on the lesion site and controllably stimulate sonosensitizer to produce a large amount of toxic reactive oxygen species (ROS). The system enables dynamic control of the ultrasound patches and allows real-time adjustments to optimize their performance in various applications, providing greater flexibility and precision in healthcare technology. Furthermore, the excellent penetration property of ultrasound into tumor tissues that induce synchronous apoptosis of tumor cells from the inside out is verified through a mouse model of breast cancer. This fully integrated conformal wearable ultrasound system provides a promising approach to noninvasively, continuously, and efficiently treat deep tumors. This work proposes a portable, wearable ultrasound system for continuous sonodynamic therapy. The integration of a multiplexed ultrasonic patch array possesses ability to accurately focus on lesion sites and produce reactive oxygen species (ROS), ultimately driving the extinction of tumor tissue from the inside out. This study provides a promising approach to noninvasively, continuously, and efficiently treat deep tumors. image