共 50 条
- [21] Precision Medicine: What Challenges Are We Facing?GENOMICS PROTEOMICS & BIOINFORMATICS, 2016, 14 (05) : 253 - 261Xue, Yu论文数: 0 引用数: 0 h-index: 0机构: Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R China Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Wuhan 430074, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaLameijer, Eric-Wubbo论文数: 0 引用数: 0 h-index: 0机构: Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaYe, Kai论文数: 0 引用数: 0 h-index: 0机构: Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Xian 710049, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaZhang, Kunlin论文数: 0 引用数: 0 h-index: 0机构: Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Xian 710049, Peoples R China Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaChang, Suhua论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaWang, Xiaoyue论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaWu, Jianmin论文数: 0 引用数: 0 h-index: 0机构: Peking Univ Canc Hosp & Inst, Ctr Canc Bioinformat, MOE Beijing Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaGao, Ge论文数: 0 引用数: 0 h-index: 0机构: Peking Univ, Sch Life Sci, Ctr Bioinformat, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaZhao, Fangqing论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaLi, Jian论文数: 0 引用数: 0 h-index: 0机构: Southeast Univ, Inst Life Sci, MOE Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaHan, Chunsheng论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaXu, Shuhua论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol PICB, Max Planck Independent Res Grp Populat Genom, Shanghai 200031, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaXiao, Jingfa论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Shanghai 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaYang, Xuerui论文数: 0 引用数: 0 h-index: 0机构: Tsinghua Univ, Sch Life Sci, Ctr Synthet & Syst Biol, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaYing, Xiaomin论文数: 0 引用数: 0 h-index: 0机构: Beijing Inst Basic Med Sci, Ctr Computat Biol, Computat Omics Lab, Beijing 100850, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaZhang, Xuegong论文数: 0 引用数: 0 h-index: 0机构: Tsinghua Univ, Bioinformat Div, Dept Automat, TNLIST, Beijing 100084, Peoples R China Tsinghua Univ, MOE Key Lab Bioinformat, Dept Automat, Beijing 100084, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaChen, Wei-Hua论文数: 0 引用数: 0 h-index: 0机构: Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Bioinformat & Syst Biol, Wuhan 430074, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaLiu, Yun论文数: 0 引用数: 0 h-index: 0机构: Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, MOE Key Lab Metab & Mol Med, Shanghai 200032, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaZhang, Zhang论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Beijing Inst Genom, BIG Data Ctr, Beijing 100101, Peoples R China Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaHuang, Kun论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, Dept Biomed Informat, Columbus, OH 43017 USA Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R ChinaYu, Jun论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Shanghai 100101, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, MOE Key Lab Mol Biophys, Wuhan 430074, Peoples R China
- [22] Precision Medicine: Unveiling Progress Amidst ChallengesINTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2024, 14 (04) : 1010 - 1018Yadav, Piyush论文数: 0 引用数: 0 h-index: 0机构: SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, India SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, IndiaSreelakshmi, M.论文数: 0 引用数: 0 h-index: 0机构: SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, India SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, IndiaChauhan, Vikas论文数: 0 引用数: 0 h-index: 0机构: IIMT Coll Pharm, Dept Pharmaceut, Greater Noida, Uttar Pradesh, India SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, IndiaMishra, Ritu论文数: 0 引用数: 0 h-index: 0机构: SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, India SGT Univ, SGT Coll Pharm, Dept Pharm Practice, Gurugram, Haryana, India
- [23] The dark genome and pleiotropy: challenges for precision medicineMAMMALIAN GENOME, 2019, 30 (7-8) : 212 - 216Brown, Steve D. M.论文数: 0 引用数: 0 h-index: 0机构: MRC Harwell Inst, Harwell OX11 0RD, Berks, England MRC Harwell Inst, Harwell OX11 0RD, Berks, EnglandLad, Heena V.论文数: 0 引用数: 0 h-index: 0机构: MRC Harwell Inst, Harwell OX11 0RD, Berks, England MRC Harwell Inst, Harwell OX11 0RD, Berks, England
- [24] Toward precision medicine in lymphoma: Challenges and opportunitiesANNALS OF ONCOLOGY, 2023, 34 : S1369 - S1369Nakamura, Hirotaka论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, JapanKunisada, Koudai论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, JapanUchiyama, Satoshi论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, JapanKaku, Eibai论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, JapanYuda, Jyunichiro论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, JapanMinami, Yosuke论文数: 0 引用数: 0 h-index: 0机构: Natl Canc Ctr East, Tokyo, Japan Natl Canc Ctr East, Tokyo, Japan
- [25] Challenges in IBD Research 2024: Precision MedicineINFLAMMATORY BOWEL DISEASES, 2024, 30 : S39 - S54Syed, Sana论文数: 0 引用数: 0 h-index: 0机构: Univ Virginia, Dept Pediat, Charlottesville, VA USA Crohns & Colitis Fdn, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USABoland, Brigid S.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Med, La Jolla, CA USA Univ Virginia, Dept Pediat, Charlottesville, VA USABourke, Lauren T.论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Precis Med Drug Dev Early Resp & Immunol, Boston, MA USA Univ Virginia, Dept Pediat, Charlottesville, VA USAChen, Lea Ann论文数: 0 引用数: 0 h-index: 0机构: Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Gastroenterol, New Brunswick, NJ USA Univ Virginia, Dept Pediat, Charlottesville, VA USAChurchill, Laurie论文数: 0 引用数: 0 h-index: 0机构: Leona M & Harry B Helmsley Charitable Trust, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USADobes, Angela论文数: 0 引用数: 0 h-index: 0机构: Crohns & Colitis Fdn, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USAGreene, Adam论文数: 0 引用数: 0 h-index: 0机构: Univ Virginia, Dept Pediat, Charlottesville, VA USAHeller, Caren论文数: 0 引用数: 0 h-index: 0机构: Crohns & Colitis Fdn, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USAJayson, Christina论文数: 0 引用数: 0 h-index: 0机构: Univ Virginia, Dept Pediat, Charlottesville, VA USAKostiuk, Benjamin论文数: 0 引用数: 0 h-index: 0机构: Crohns & Colitis Fdn, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USAMoss, Alan论文数: 0 引用数: 0 h-index: 0机构: Crohns & Colitis Fdn, New York, NY USA 733 3rd Ave,Suite 510, New York, NY 10017 USA Univ Virginia, Dept Pediat, Charlottesville, VA USANajdawi, Fedaa论文数: 0 引用数: 0 h-index: 0机构: PathAI, Boston, MA USA Univ Virginia, Dept Pediat, Charlottesville, VA USAPlung, Lori论文数: 0 引用数: 0 h-index: 0机构: Crohns & Colitis Fdn, New York, NY USA Univ Virginia, Dept Pediat, Charlottesville, VA USARioux, John D.论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Montreal Heart Inst, Res Ctr, Montreal, PQ, Canada Univ Virginia, Dept Pediat, Charlottesville, VA USARosen, Michael J.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Sch Med, Dept Pediat, Div Pediat Gastroenterol, Stanford, CA USA Univ Virginia, Dept Pediat, Charlottesville, VA USATorres, Joana论文数: 0 引用数: 0 h-index: 0机构: Hosp Beatriz Angelo, Hosp Luz, Div Gastroenterol, Lisbon, Portugal Univ Lisbon, Fac Med, Lisbon, Portugal Univ Virginia, Dept Pediat, Charlottesville, VA USAZulqarnain, Fatima论文数: 0 引用数: 0 h-index: 0机构: Univ Virginia, Dept Pediat, Charlottesville, VA USASatsangi, Jack论文数: 0 引用数: 0 h-index: 0机构: Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Translat Gastroenterol Unit,Expt Med Div, Oxford, England Univ Virginia, Dept Pediat, Charlottesville, VA USA
- [26] Preparing pathology for precision medicine: challenges and opportunitiesVirchows Archiv, 2017, 471 : 141 - 146Karen L Kaul论文数: 0 引用数: 0 h-index: 0机构: NorthShore University HealthSystem,Department of Pathology and Laboratory Medicine
- [27] Precision Medicine:What Challenges Are We Facing?Genomics,Proteomics & Bioinformatics, 2016, (05) : 253 - 261Yu Xue论文数: 0 引用数: 0 h-index: 0机构: MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology论文数: 引用数: h-index:机构:Kai Ye论文数: 0 引用数: 0 h-index: 0机构: School of Electronic and Information Engineering,Xi’an Jiaotong University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyKunlin Zhang论文数: 0 引用数: 0 h-index: 0机构: CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologySuhua Chang论文数: 0 引用数: 0 h-index: 0机构: CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyXiaoyue Wang论文数: 0 引用数: 0 h-index: 0机构: State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology论文数: 引用数: h-index:机构:Ge Gao论文数: 0 引用数: 0 h-index: 0机构: Center for Bioinformatics,State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences,Peking University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyFangqing Zhao论文数: 0 引用数: 0 h-index: 0机构: Beijing Institutes of Life Science,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyJian Li论文数: 0 引用数: 0 h-index: 0机构: MOE Key Laboratory of Developmental Genes and Human Disease,Institute of Life Sciences,Southeast University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyChunsheng Han论文数: 0 引用数: 0 h-index: 0机构: State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyShuhua Xu论文数: 0 引用数: 0 h-index: 0机构: Max Planck Independent Research Group on Population Genomics,CAS-MPG Partner Institute for Computational Biology(PICB),Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyJingfa Xiao论文数: 0 引用数: 0 h-index: 0机构: CAS Key Laboratory of Genome Sciences and Information,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyXuerui Yang论文数: 0 引用数: 0 h-index: 0机构: MOE Key Laboratory of Bioinformatics,School of Life Sciences,Center for Synthetic and Systems Biology,Tsinghua University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyXiaomin Ying论文数: 0 引用数: 0 h-index: 0机构: Computational Omics Laboratory,Center of Computational Biology,Beijing Institute of Basic Medical Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyXuegong Zhang论文数: 0 引用数: 0 h-index: 0机构: Bioinformatics Division,TNLIST and MOE Key Laboratory for Bioinformatics,Department of Automation,Tsinghua University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyWei-Hua Chen论文数: 0 引用数: 0 h-index: 0机构: Department of Bioinformatics and Systems Biology,College of Life Science and Technology,Huazhong University of Science and Technology MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyYun Liu论文数: 0 引用数: 0 h-index: 0机构: MOE Key Laboratory of Metabolism and Molecular Medicine,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Fudan University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyZhang Zhang论文数: 0 引用数: 0 h-index: 0机构: BIG Data Center and CAS Key Laboratory of Genome Sciences & Information,Beijing Institute of Genomics,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyKun Huang论文数: 0 引用数: 0 h-index: 0机构: Department of Biomedical Informatics,The Ohio State University MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and TechnologyJun Yu论文数: 0 引用数: 0 h-index: 0机构: CAS Key Laboratory of Genome Sciences and Information,Chinese Academy of Sciences MOE Key Laboratory of Molecular Biophysics,College of Life Science and Technology and the Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology
- [28] The promise and challenges of precision medicine in dilated cardiomyopathyEUROPEAN HEART JOURNAL-CASE REPORTS, 2021, 5 (11)Mason, Samantha论文数: 0 引用数: 0 h-index: 0机构: Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, England Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, EnglandQuinn, Ellie论文数: 0 引用数: 0 h-index: 0机构: Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, England Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, EnglandHalliday, Brian P.论文数: 0 引用数: 0 h-index: 0机构: Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, England Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6NP, England Royal Brompton Hosp, Inherited Cardiovasc Condit Care Grp, Sydney St, London SW3 6NP, England
- [29] Proteomics and phosphoproteomics in precision medicine: applications and challengesBRIEFINGS IN BIOINFORMATICS, 2019, 20 (03) : 767 - 777Giudice, Girolamo论文数: 0 引用数: 0 h-index: 0机构: EMBL EBI, Petsalaki Grp, Cambridge, England EMBL EBI, Petsalaki Grp, Cambridge, EnglandPetsalaki, Evangelia论文数: 0 引用数: 0 h-index: 0机构: EMBL EBI, Cambridge, England EMBL EBI, Petsalaki Grp, Cambridge, England
- [30] Challenges and opportunities for precision medicine in neurodevelopmental disordersADVANCED DRUG DELIVERY REVIEWS, 2022, 191Chen, George T.论文数: 0 引用数: 0 h-index: 0机构: UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA UCLA, Semel Inst, Ctr Autism Res & Treatment, David Geffen Sch Med, Los Angeles, CA USA UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USAGeschwind, Daniel H.论文数: 0 引用数: 0 h-index: 0机构: UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA UCLA, Semel Inst, Ctr Autism Res & Treatment, David Geffen Sch Med, Los Angeles, CA USA UCLA, Semel Inst, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA UCLA, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA UCLA, Inst Precis Hlth, Los Angeles, CA USA UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA