Network Meta-Analysis: Effect of Cold Stress on the Gene Expression of Swine Adipocytes ATGL, CIDEA, UCP2, and UCP3

被引:1
|
作者
Guo, Zhenhua [1 ]
Lv, Lei [2 ]
Liu, Di [1 ]
Ma, Hong [1 ]
Wang, Liang [1 ]
Fu, Bo [1 ]
Wang, Fang [1 ]
机构
[1] Inst Anim Husb, Heilongjiang Acad Agr Sci, Key Lab Combining Farming & Anim Husb, Minist Agr & Rural Affairs, 368 Xuefu Rd, Harbin 150086, Peoples R China
[2] Heilongjiang Acad Forestry, Wood Sci Res Inst, 134 Haping Rd, Harbin 150080, Peoples R China
基金
中国国家自然科学基金;
关键词
beige adipose tissue; fat; pig; UCP1; CORTICOSTERONE; METABOLISM;
D O I
10.3390/cimb46050240
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cold stress significantly affects gene expression in adipocytes; studying this phenomenon can help reveal the pathogeneses of conditions such as obesity and insulin resistance. Adipocyte triglyceride lipase (ATGL); cell death-inducing deoxyribonucleic acid (DNA) fragmentation factor subunit alpha (DFFA)-like effector (CIDEA); and uncoupling protein genes UCP1, UCP2, and UCP3 are the most studied genes in pig adipose tissues under cold stress. However, contradictory results have been observed in gene expression changes to UCP3 and UCP2 when adipose tissues under cold stress were examined. Therefore, we conducted a meta-analysis of 32 publications in total on the effect of cold stress on the expression of ATGL, CIDEA, UCP2, and UCP3. Our results showed that cold stress affected the expression of swine adipocyte genes; specifically, it was positively correlated with the expression of UCP3 in swine adipocytes. Conversely, expression of ATGL was negatively affected under cold stress conditions. In addition, the loss of functional UCP1 in pigs likely triggered a compensatory increase in UCP3 activity. We also simulated the docking results of UCP2 and UCP3. Our results showed that UCP2 could strongly bind to adenosine triphosphate (ATP), meaning that UCP3 played a more significant role in pig adipocytes.
引用
收藏
页码:3866 / 3876
页数:11
相关论文
共 50 条
  • [31] Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa
    Hu, X
    Murphy, F
    Karwautz, A
    Li, T
    Freeman, B
    Franklin, D
    Giotakis, O
    Treasure, J
    Collier, DA
    MOLECULAR PSYCHIATRY, 2002, 7 (03) : 276 - 277
  • [32] Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa
    X Hu
    F Murphy
    A Karwautz
    T Li
    B Freeman
    D Franklin
    O Giotakis
    J Treasure
    D A Collier
    Molecular Psychiatry, 2002, 7 (3) : 276 - 277
  • [33] Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women
    Cha, Min Ho
    Kim, Il Chul
    Kim, Kil Soo
    Kang, Byoung Kab
    Choi, Sun Mi
    Yoon, Yoosik
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2007, 56 (06): : 806 - 813
  • [34] Uncoupling protein-2 (UCP2) and uncoupling protein-3 (UCP3) expression in adipose tissue and skeletal muscle in humans
    Langin, D
    Larrouy, D
    Barbe, P
    Millet, L
    Viguerie-Bascands, N
    Andreelli, F
    Laville, M
    Vidal, H
    INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (Suppl 6) : S64 - S67
  • [35] Uncoupling protein-2 (UCP2) and uncoupling protein-3 (UCP3) expression in adipose tissue and skeletal muscle in humans
    D Langin
    D Larrouy
    P Barbe
    L Millet
    N Viguerie-Bascands
    F Andreelli
    M Laville
    H Vidal
    International Journal of Obesity, 1999, 23 : S64 - S67
  • [36] Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen
    Pedersen, SB
    Bruun, JM
    Kristensen, K
    Richelsen, B
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (01) : 191 - 197
  • [37] Erratum: Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa
    X Hu
    F Murphy
    A Karwautz
    T Li
    O Giotakis
    J Treasure
    D A Collier
    Molecular Psychiatry, 2002, 7 : 814 - 814
  • [38] Triiodothyronine up-regulates in vivo and in vitro the expression of UCP2 and UCP3 mRNA in human skeletal muscle and adipose tissue
    Langin, D
    Larrouy, D
    Boulanger, C
    Chevillotte, E
    Viguerie, N
    Thalamas, C
    Roques, M
    Vidal, H
    Barbe, P
    OBESITY RESEARCH, 2000, 8 : 48S - 48S
  • [39] Metformin causes oxidative stress and up-regulates expression of UCP2 in white adipocytes
    Anedda, Andrea
    Rial, Eduardo
    Gonzalez-Barroso, Mar
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 : S49 - S50
  • [40] Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet
    P Schrauwen
    H Hoppeler
    R Billeter
    AHF Bakker
    DR Pendergast
    International Journal of Obesity, 2001, 25 : 449 - 456