Neonatal bacterial sepsis

被引:8
|
作者
Strunk, Tobias [1 ,2 ]
Molloy, Eleanor J. [3 ,4 ,5 ,6 ,7 ,8 ]
Mishra, Archita [2 ]
Bhutta, Zulfiqar A. [9 ,10 ]
机构
[1] King Edward Mem Hosp, Child & Adolescent Hlth Serv, Neonatal Directorate, Perth, WA 6008, Australia
[2] Univ Western Australia, Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth, WA, Australia
[3] Univ Dublin, Trinity Coll, Discipline Paediat, Dublin, Ireland
[4] Trinity Res Childhood Ctr, Dublin, Ireland
[5] Tallaght Univ Hosp, Childrens Hlth Hosp Tallaght, Dublin, Ireland
[6] St James Hosp, Trinity Translat Med Inst, Dublin, Ireland
[7] Childrens Hlth Hosp Crumlin, Neonatol, Dublin, Ireland
[8] Coombe Womens & Infants Univ Hosp, Paediat, Dublin, Ireland
[9] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada
[10] Aga Khan Univ South Cent Asia, Inst Global Hlth & Dev, Karachi, Pakistan
来源
LANCET | 2024年 / 404卷 / 10449期
关键词
EARLY-ONSET SEPSIS; GROUP-B STREPTOCOCCUS; SMALL VULNERABLE NEWBORNS; SOUTH-ASIA ANISA; ANTIBIOTIC USE; GLOBAL BURDEN; UMBILICAL-CORD; BLOOD CULTURE; SYSTEMATIC ANALYSIS; PREMATURE-INFANTS;
D O I
10.1016/S0140-6736(24)00495-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neonatal sepsis remains one of the key challenges of neonatal medicine, and together with preterm birth, causes almost 50% of all deaths globally for children younger than 5 years. Compared with advances achieved for other serious neonatal and early childhood conditions globally, progress in reducing neonatal sepsis has been much slower, especially in low-resource settings that have the highest burden of neonatal sepsis morbidity and mortality. By contrast to sepsis in older patients, there is no universally accepted neonatal sepsis definition. This poses substantial challenges in clinical practice, research, and health-care management, and has direct practical implications, such as diagnostic inconsistency, heterogeneous data collection and surveillance, and inappropriate treatment, health-resource allocation, and education. As the clinical manifestation of neonatal sepsis is frequently non-specific and the current diagnostic standard blood culture has performance limitations, new improved diagnostic techniques are required to guide appropriate and warranted antimicrobial treatment. Although antimicrobial therapy and supportive care continue as principal components of neonatal sepsis therapy, refining basic neonatal care to prevent sepsis through education and quality improvement initiatives remains paramount.
引用
收藏
页码:277 / 293
页数:17
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