The aim of this study was to explore the effects of the Israeli Lifestyle Program (ILP) on older adults' quality of life (QoL) and depressive symptoms. The study employed a non-randomized controlled pre-post intervention design, (N = 99), ages 60+ years, living independently in the community. The ILP group (n = 79) participated in 15 weekly group meetings and two individual sessions. The control group (n = 20) received an educational booklet based on the ILP content. Participants completed the (WHOQoL-BREF) and a Personal Health Questionnaire (PHQ-9) pre and post intervention. At baseline, no significant differences were found between the groups. Post-intervention, the ILP group values improved in the psychological (p < .001, eta(2) = .154), social relationship (p < .001, eta(2) = .131), and environmental (p = .002, eta(2) = .105) domains of the WHOQoL- BREF, whereas no change was found in these domains among the control group. Physical QoL increased beyond group (p = .020, eta(2) = .056), although not significantly. ILP participants showed no change in the depressive symptom report (p = .424, eta(2) = .007), whereas participants in the control group, reported more depressive symptoms (p = .009, eta(2) = .070). The ILP was found to increase participants' QoL and deemed as a promising health enhancement intervention for community-dwelling older adults.