Effects of crotamine in human prostate cancer cell line

被引：0
|
作者：
Alberghini-dos-Santos, Joao Victor [1 ]
Sanchez, Caroline Andolfato [2 ]
Bordon, Karla de Castro Figueiredo [1 ]
Pucca, Manuela Berto [3 ,4 ]
Antunes, Lusania Maria Greggi [2 ]
Arantes, Eliane Candiani [1 ]
Oliveira, Isadora Sousa de [1 ]
机构：
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ave Cafe Ave S-N, BR-14040903 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto, SP, Brazil
[3] Univ Fed Roraima, Hlth & Sci Postgrad Program, Boa Vista, RR, Brazil
[4] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP, Brazil
来源：
TOXICON | 2024年 / 243卷
关键词：
Snake venoms; Crotalus durissus terrificus; Anticancer; CPP; DU-145; RATTLESNAKE; MYOTOXIN; ASSAY; VENOM; MITOCHONDRIA; EXPRESSION; CHANNELS; PROTEIN; CALCIUM; KV1.3;
D O I：
10.1016/j.toxicon.2024.107746
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Our study presents the anticancer potential of crotamine from Crotalus durissus terrificus in human prostate cancer cell line DU-145. Crotamine isolation was conducted through RP-FPLC, its molecular mass analyzed by MALDITOF was 4881.4 kDa, and N-terminal sequencing confirmed crotamine identity. Crotamine demonstrated no toxicity and did not inhibit migration in HUVEC cells. Although no cell death occurred in DU-145 cells, crotamine inhibited their migration. Thus, crotamine presented potential to be a prototype of anticancer drug.
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页数：6
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