Tumor flare with T-cell-engaging bispecific antibodies

被引:0
|
作者
Carlo-Stella, Carmelo [1 ,2 ]
Dickinson, Michael J. [3 ]
Iacoboni, Gloria [4 ,5 ]
Carpio, Cecilia [4 ]
Dimier, Natalie [6 ]
Weisser, Martin [7 ]
Kwan, Antonia [8 ]
Ferlini, Cristiano [9 ]
机构
[1] Humanitas Univ, Dept Biomed Sci, Rozzano, Milano, Italy
[2] IRCCS Humanitas Res Hosp, Dept Oncol & Hematol, Rozzano, Milano, Italy
[3] Royal Melbourne Hosp, PeterMacCallum Canc Ctr, Melbourne, Vic, Australia
[4] Vall dHebron Hosp Univ, Vall dHebron Inst Oncol VHIO, Dept Hematol, Expt Hematol, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain
[5] Univ Autonoma Barcelona, Dept Med, Bellaterra, Spain
[6] Roche Prod Ltd, Welwyn Garden City, England
[7] Roche Innovat Ctr Munich, Roche Pharm Res & Early Dev, Penzberg, Germany
[8] Genentech Inc, Prod Dev Safety, South San Francisco, CA USA
[9] Roche Innovat Ctr New York, Roche Pharm Res & Early Dev, New York, NY USA
关键词
D O I
10.1080/10428194.2024.2361100
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
    Yu, Lin
    Huang, Nan
    Ge, Liangpeng
    Sun, Heng
    Fu, Yuna
    Liu, Chundong
    Wang, Jianhua
    [J]. JOURNAL OF BIOLOGICAL ENGINEERING, 2021, 15 (01)
  • [42] GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma
    Jeong A. Park
    Nai-Kong V. Cheung
    [J]. Journal of Hematology & Oncology, 13
  • [43] GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma
    Park, Jeong A.
    Cheung, Nai-Kong V.
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
  • [44] Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
    Lin Yu
    Nan Huang
    Liangpeng Ge
    Heng Sun
    Yuna Fu
    Chundong Liu
    Jianhua Wang
    [J]. Journal of Biological Engineering, 15
  • [45] CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330
    Krupka, Christina
    Kufer, Peter
    Kischel, Roman
    Zugmaier, Gerhard
    Boegeholz, Jan
    Koehnke, Thomas
    Lichtenegger, Felix S.
    Schneider, Stephanie
    Metzeler, Klaus H.
    Fiegl, Michael
    Spiekermann, Karsten
    Baeuerle, Patrick A.
    Hiddemann, Wolfgang
    Riethmueller, Gert
    Subklewe, Marion
    [J]. BLOOD, 2014, 123 (03) : 356 - 365
  • [46] Incorporation of a repeated polypeptide sequence in therapeutic antibodies as a universal masking procedure: A case study of T cell-engaging bispecific antibodies
    Maejima, Atsushi
    Suzuki, Saori
    Makabe, Koki
    Kumagai, Izumi
    Asano, Ryutaro
    [J]. NEW BIOTECHNOLOGY, 2023, 77 : 80 - 89
  • [47] Nonclinical Investigation of Cytokine Mitigation Strategies for T-cell-Engaging Bispecifics in the Cynomolgus Macaque
    Kamperschroer, Cris
    Guffroy, Magali
    Shen, Amy
    Dokmanovich, Melba
    Stubbs, Makeida
    O'Donnell, Lynn M.
    [J]. JOURNAL OF IMMUNOTHERAPY, 2024, 47 (05) : 160 - 171
  • [48] T-cell-engaging B7-H4/CD3 bispecific Fab-scFv antibody targeting human breast cancer
    Iizuka, Akira
    Ashizawa, Tadashi
    Ohshima, Keiichi
    Kusuhara, Masatoshi
    Yamaguchi, Ken
    Akiyama, Yasuto
    [J]. CANCER SCIENCE, 2018, 109 : 413 - 413
  • [49] T-cell surface generation of dual bivalent, bispecific T-cell engaging, RNA duplex cross-linked antibodies (dbBiTERs) for re-directed tumor cell lysis
    Kujawski, Maciej
    Li, Lin
    Li, Harry
    Yazaki, Paul J.
    Swiderski, Piotr
    Shively, John E.
    [J]. BIOTECHNOLOGY JOURNAL, 2022, 17 (02)
  • [50] SOHO State of the Art Updates and Next Questions: T-Cell-Directed Immune Therapies for Multiple Myeloma: Chimeric Antigen Receptor-Modified T Cells and Bispecific T-Cell-Engaging Agents
    Madduri, Deepu
    Dhodapkar, Madhav, V
    Lonial, Saar
    Jagannath, Sunday
    Cho, Hearn Jay
    [J]. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (09): : 537 - 544