Discovery and characterization of QTX3544, a potent, selective, and orally bioavailable allosteric G12V preferring multi KRAS inhibitor

被引：0
|
作者：
Zhang, Yang W.
Vo, Elizabeth Donohue
Gan, Pei
Rominger, Dave
Silva, Jillian M.
Zhang, Yang J.
Pan, Christopher
Lee, Greg
Micozzi, John M.
Ben Reid
McDonough, Brooke
Sinha, Arghyotri
Hospital, Audrey
Krauth, Doug
Luengo, Juan I.
Kramer, Mike
Pitt, Cameron
Lin, Hong
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2024-LB163
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB163
引用
下载
收藏
页数：2
相关论文
共 21 条
  • [21] Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor
    Lapierre, Jean-Marc
    Eathiraj, Sudharshan
    Vensel, David
    Liu, Yanbin
    Bull, Cathy O.
    Cornell-Kennon, Susan
    Iimura, Shin
    Kelleher, Eugene W.
    Kizer, Darin E.
    Koerner, Steffi
    Makhija, Sapna
    Matsuda, Akihisa
    Moussa, Magdi
    Namdev, Nivedita
    Savage, Ronald E.
    Szwaya, Jeff
    Volckova, Erika
    Westlund, Neil
    Wu, Hui
    Schwartz, Brian
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (13) : 6455 - 6469
123