Corrected QT interval and QT dispersion in temporal lobe epilepsy in children and adolescent

Aim : The purpose of this research was to contrast (heart-rate corrected QT interval) QTc, and (QT dispersion) QTd intervals in individuals with (temporal lobe epilepsy) TLE and those without TLE using a standard 12-lead electrocardiogram. Patients & methods : This cross-sectional research was undertaken on 100 cases aged 10 to 20 diagnosed with epilepsy in accordance with 2017 ILAE criteria. The patients ' informed written permission was acquired. In our study, we included 100 cases: 50 with TLE and 50 with non-TLE verified by seizure semiology. All patients were subjected to a comprehensive history, clinical examination (heart rate, pulse, and blood pressure), and clinical evaluation, which included a comprehensive epilepsy history. On the basis of neurology service documents or the initial publication of the international classification of diseases, 9 th revision (ICD9) diagnostic or 10 th revision (ICD10) codes for epilepsy, diagnostic age for epilepsy was calculated. Results: The mean QT interval in group I was 418.30 +/- 25.48 ms while that of group II was 406.20 +/- 27.63 ms, the mean QTc of group I was 513.60 +/- 61.94 ms and was 488.70 +/- 50.65 in group II. The calculated QTd was with a mean of 57.60 +/- 25.05 ms while that of group II was 43.60 +/- 31.89 ms. It means that the QT interval, QTc, and QTd values were considerably greater in the group I (temporal epilepsy) contrasted with group II (non-temporal epilepsy); (p=0.025, 0.030, and 0.016, respectively). The mean QT, QTc, and QTd values for FE were 409.20 +/- 20.80, 500.70 +/- 55.60, and 52.60 +/- 29.70 ms, respectively. QT, QTc, and QTd mean values for patients with widespread epilepsy were 412.00 +/- 25.60, 505.00 +/- 68.60, and 46.20 +/- 28.70 ms. QT, QTc, and QTd interval were insignificantly different between focal and generalized epilepsy. The longer an illness progresses, the longer the QT and QTc intervals, as there was a substantial positive correlation among illness 's course and QT interval (r=0.391, p<0.001) and QTc interval (r=0.289, p=0.011), but there was no noticeable impact on QTd due to the illness 's duration, as we found an insignificant correlation among duration of illness and QTC and QTd. Conclusions: Our findings indicate that; QTc interval and QTd are longer in epilepsy cases more among TLE cases contrasted with non-TLE. Since there was no distinction among different epilepsy types (focal and generalized).