Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases

被引:4
|
作者
Chen, Luxia [1 ]
Lei, Xuan [1 ]
Mahnke, Karsten [1 ]
机构
[1] Univ Hosp Heidelberg, Dept Dermatol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany
关键词
adenosine receptors; inflammation; psoriasis; hyperplasia; immunosuppression; PLAQUE-TYPE PSORIASIS; ORAL CF101 DATA; MOUSE MODEL; KERATINOCYTE PROLIFERATION; INTERNATIONAL UNION; TOPICAL APPLICATION; A(2B) RECEPTORS; IL-6; PRODUCTION; GLUCOSE-UPTAKE; UP-REGULATION;
D O I
10.3390/ijms25115810
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies, involving a multiplicity of mediators and cell types, including immune and non-immune cells. Adenosine, a ubiquitous endogenous immune modulator, generated from adenosine triphosphate (ATP), acts via four G protein-coupled receptors (A1, A2A, A2B, and A3). Given the widespread expression of those receptors and their regulatory effects on multiple immune signaling pathways, targeting adenosine receptors emerges as a compelling strategy for anti-inflammatory intervention. Animal models of psoriasis, contact hypersensitivity (CHS), and other dermatitis have elucidated the involvement of adenosine receptors in the pathogenesis of these conditions. Targeting adenosine receptors is effective in attenuating inflammation and remodeling the epidermal structure, potentially showing synergistic effects with fewer adverse effects when combined with conventional therapies. What is noteworthy are the promising outcomes observed with A2A agonists in animal models and ongoing clinical trials investigating A3 agonists, underscoring a potential therapeutic approach for the management of inflammatory skin disorders.
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页数:22
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