Emerging Theranostics for Prostate Cancer and a Model of Prostate-specific Membrane Antigen Therapy

被引：2
|
作者：
Jewell, Kerry [1 ,2 ]
Hofman, Michael S. [1 ,2 ,3 ]
Ong, Jeremy S. L. [2 ,4 ]
Levy, Sidney [1 ]
机构：
[1] Peter MacCallum Canc Ctr, Mol Imaging & Therapeut Nucl Med, 305 Grattan St, Melbourne, Vic 3000, Australia
[2] Peter MacCallum Canc Ctr, Prostate Theranost & Imaging Ctr Excellence ProsTI, Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia
[3] Univ Melbourne, Melbourne, Australia
[4] Fiona Stanley Hosp, Dept Nucl Med, Murdoch, Australia
来源：
RADIOLOGY | 2024年 / 311卷 / 01期
关键词：
RADIOLIGAND THERAPY; CLINICAL UTILITY; NORMAL PATTERNS; OPEN-LABEL; TRIAL; PET; MULTICENTER; MANAGEMENT; DOSIMETRY; VISION;
D O I：
10.1148/radiol.231703
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
There is increasing demand worldwide to develop diagnostic and therapeutic (theranostic) markers for prostate cancer. One target of interest is prostate-specific membrane antigen (PSMA), a protein which is overexpressed in prostate cancer cells. Over the past decade, a growing body of literature has demonstrated that radiolabeled ligands that target PSMA show favorable clinical response and survival outcomes in patients with advanced prostate cancer. This focused review provides background to the development of PSMA as a target, an overview of key studies informing our current approach to radioligand-based imaging and therapy for prostate cancer, and a model for real-world implementation of PSMA theranostics based on an Australian experience.
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页数：10
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