Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis

被引:0
|
作者
Krueger, J. G. [1 ]
Garcet, S. [1 ]
Cheng, J. [2 ]
Kumar, S. [3 ]
Tang, J. [3 ]
Blau, J. [2 ]
Zhao, Y. [2 ]
Zhang, W. [2 ]
Saha, B. [2 ]
Arunachalam, V. [3 ]
Heap, G. A. [2 ]
Thakker, P. [2 ]
Choudhury, A. [2 ]
机构
[1] Rockefeller Univ, Lab Invest Dermatol, New York, NY USA
[2] Takeda Pharmaceut Int Co, Gastrointestinal & Inflammat Therapeut Unit, Cambridge, MA USA
[3] Takeda Pharmaceut Int Co, Gastrointestinal & Inflammat Therapeut Unit, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
265
引用
收藏
页码:S46 / S46
页数:1
相关论文
共 50 条
  • [41] Pharmacodynamic Response to Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in a Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled Psoriasis Trial
    Catlett, Ian M.
    Gao, Lu
    Hu, Yanhua
    Banerjee, Subhashis
    Krueger, James G.
    DERMATOLOGY AND THERAPY, 2024, 14 (10) : 2827 - 2839
  • [42] Evaluating the influence of baseline disease characteristics on efficacy of a selective oral TYK2 inhibitor, BMS-986165, in patients with moderate-to-severe plaque psoriasis in a phase 2 trial
    Gordon, Kenneth
    Papp, Kim
    Gooderham, Melinda
    Thaci, Diamant
    Foley, Peter
    Banerjee, Subhashis
    Kundu, Sudeep
    Kisa, Renata
    Napoli, Andrew
    Morita, Akimichi
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2019, 81 (04) : AB59 - AB59
  • [43] Deucravacitinib, an oral, selective tyrosine kinase 2 (TYK2) inhibitor, versus placebo and apremilast in moderate/severe plaque psoriasis: onset of action in the phase 3 POETYK PSO-1 and PSO-2 trials
    Foley, Peter
    AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2022, 63 : 65 - 65
  • [44] EFFICACY AND SAFETY OF DEUCRAVACITINIB, AN ORAL, SELECTIVE TYROSINE KINASE 2 (TYK2) INHIBITOR, COMPARED WITH PLACEBO AND APREMILAST IN MODERATE TO SEVERE PLAQUE PSORIASIS: RESULTS FROM THE PHASE 3 POETYK PSO-1 STUDY
    Armstrong, A.
    Gooderham, M.
    Warren, R. B.
    Papp, K.
    Strober, B.
    Thaci, D.
    Colston, E.
    Throup, J.
    Kundu, S.
    Banerjee, S.
    Blauvelt, A.
    ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 : 795 - 796
  • [45] Deucravacitinib, an oral, selective tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate to severe plaque psoriasis who had inadequate responses to apremilast at week 24 in the phase 3 POETYK PSO-1 and PSO-2 trials
    Armstrong, April W.
    Warren, Richard B.
    Sofen, Howard
    Spelman, Lynda
    Leonardi, Craig
    Banerjee, Subhashis
    Wang, Tao
    Throup, John
    Colston, Elizabeth
    Napoli, Andrew
    Kimball, Alexa B.
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2022, 87 (03) : AB156 - AB156
  • [46] Evaluating influence of baseline characteristics on efficacy of a selective oral TYK2 inhibitor, BMS-986165, in patients with moderate-to-severe plaque psoriasis in a Phase 2 trial
    Gordon, K.
    Papp, K.
    Gooderham, M.
    Thaci, D.
    Foley, P.
    Morita, A.
    Kundu, S.
    Kisa, R.
    Napoli, A.
    Banerjee, S.
    EXPERIMENTAL DERMATOLOGY, 2018, 27 : 29 - 30
  • [47] Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Versus Placebo and Apremilast in Moderate to Severe Plaque Psoriasis: Achievement of Absolute PASI Thresholds in the Phase 3 POETYK PSO-1 and PSO-2 Trials
    Thaci, Diamant
    Lebwohl, Mark
    Gooderham, Melinda
    Warren, Richard B.
    Foley, Peter
    Gottlieb, Alice B.
    Banerjee, Subhashis
    Hippeli, Lauren
    Kisa, Renata
    Griffiths, Christopher
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2023, 21 : 119 - 120
  • [48] Deucravacitinib, an oral, selective tyrosine kinase 2 (TYK2) inhibitor, versus placebo and apremilast in moderate to severe plaque psoriasis: Achievement of absolute PASI thresholds in the phase 3 POETYK PSO-1 and PSO-2 trials
    Lebwohl, Mark
    Gooderham, Melinda
    Warren, Richard B.
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2022, 87 (03) : AB41 - AB41
  • [49] DESIGN OF 2 PHASE 3, DOUBLE-BLIND, PLACEBO-CONTROLLED, GLOBAL TRIALS OF DEUCRAVACITINIB, AN ORAL, SELECTIVE, ALLOSTERIC TYROSINE KINASE 2 (TYK2) INHIBITOR, IN PATIENTS WITH ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS
    Arriens, C.
    Askanase, A.
    Furie, R.
    Morand, E. F.
    Van Vollenhoven, R.
    Connors, K.
    Davey, M.
    Delev, N.
    Shah, V.
    Stevens, A.
    Wegman, T.
    Hobar, C.
    ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 : 1463 - 1463
  • [50] Deucravacitinib, an oral, selective tyrosine kinase 2 (TYK2) inhibitor, in moderate to severe plaque psoriasis: 52-week efficacy results from the phase 3 POETYK PSO-1 and POETYK PSO-2 trials
    Spelman, Lynda
    AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2022, 63 : 66 - 66