Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents

被引：0

作者：

Gonzalez-Gonzalez, Alonzo ^{[1
]}

Sanchez-Sanchez, Oscar ^{[1
]}

Wan, Baojie ^{[2
]}

Franzblau, Scott ^{[2
]}

Palos, Isidro ^{[3
]}

Espinoza-Hicks, Jose C. ^{[4
]}

Moreno-Rodriguez, Adriana ^{[5
]}

Martinez-Vazquez, Ana Veronica ^{[1
]}

Lara-Ramirez, Edgar E. ^{[1
]}

Ortiz-Perez, Eyra ^{[1
]}

Paz-Gonzalez, Alma D. ^{[1
]}

Rivera, Gildardo ^{[1
]}

机构：

[1] Inst Politecn Nacl, Lab Biotecnol Farmaceut, Ctr Biotecnol Genom, Reynosa, Mexico

[2] Univ Illinois, Inst TB Res, Coll Pharm, Chicago, IL USA

[3] Univ Autonoma Tamaulipas, Unidad Academ Multidisciplinaria Reynosa Rodhe, Ciudad Victoria, Mexico

[4] Univ Autonoma Chihuahua, Fac Ciencias Quim, Chihuahua, Mexico

[5] Univ Autonoma Benito Juarez Oaxaca, Fac Ciencias Quim, Lab Estudios Epidemiol Clin Disenos Expt & Invest, Oaxaca, Mexico

来源：

RSC MEDICINAL CHEMISTRY | 2024年 / 15卷 / 08期

关键词：

QUINOXALINE; CLOFAZIMINE;

D O I：

10.1039/d4md00221k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tuberculosis is a worldwide health problem that warrants attention given that the current treatment options require a long-term chemotherapeutic period and have reported the development of Mycobacterium tuberculosis (M. tuberculosis) multidrug resistant strains. In this study, n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide were evaluated against replicating and non-replicating H37Rv M. tuberculosis strains. The results showed that seventeen of the twenty-eight derivatives have minimum inhibitory concentration (MIC) values lower than isoniazid (2.92 mu M). The most active antimycobacterial agents were T-148, T-149, T-163, and T-164, which have the lowest MIC values (0.53, 0.57, 0.53, and 0.55 mu M respectively). These results confirm the potential of quinoxaline-1,4-di-N-oxide against M. tuberculosis to develop and obtain new and more safety antituberculosis drugs.

引用

页码：2785 / 2791

页数：7

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