Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

被引：0

作者：

Rodriguez-Fernandez, Blanca ^{[1
,2
,3
,4
]}

Sanchez-Benavides, Gonzalo ^{[1
,2
,5
]}

Genius, Patricia ^{[1
,2
,3
]}

Minguillon, Carolina ^{[1
,2
,5
]}

Fauria, Karine ^{[1
,5
]}

De Vivo, Immaculata ^{[6
,7
]}

Navarro, Arcadi ^{[1
,3
,8
,9
]}

Molinuevo, Jose Luis ^{[1
,15
]}

Gispert, Juan Domingo ^{[1
,2
,10
,11
]}

Sala-Vila, Aleix ^{[1
,2
]}

Vilor-Tejedor, Natalia ^{[1
,2
,3
,12
,13
]}

Crous-Bou, Marta ^{[1
,5
,12
,14
]}

机构：

[1] Pasqual Maragall Fdn, Barcelonabeta Brain Res Ctr BBRC, C Wellington 30, Barcelona 08005, Spain

[2] IMIM Hosp del Mar Med Res Inst, C Dr Aiguader 88,2nd Floor,Campus Mar, Barcelona 08003, Spain

[3] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, C Dr Aiguader 88, Barcelona 08003, Spain

[4] Univ Autonoma Barcelona, Barcelona 08193, Spain

[5] Inst Salud Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[6] Harvard TH Chan Sch Publ Hlth, Sch Publ Hlth 2, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA

[7] Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA

[8] Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Pg Maritim Barceloneta 37, Barcelona 08003, Spain

[9] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

[10] Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[11] Ctr Nacl Invest Cardiovasc CNIC, C Melchor Fernandez Almagro 3, Madrid 28029, Spain

[12] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[13] Univ Pompeu Fabra, C Ramon Trias Fargas 25,27, Barcelona 08005, Spain

[14] Hosp Duran & Reynals, Catalan Inst Oncol ICO, Bellvitge Biomed Res Ctr IDIBELL, Avinguda Granvia Hospitalet 199-203, Barcelona 08908, Spain

[15] H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Copenhagen, Denmark

来源：

NEUROBIOLOGY OF AGING | 2024年 / 141卷

关键词：

Alzheimer's disease; Biological aging; Cognitive performance; Sex differences; Telomere length; MINI-MENTAL STATE; METAANALYSIS; POPULATION; DEMENTIA; VERSION; RECALL; ADULTS;

D O I：

10.1016/j.neurobiolaging.2024.05.015

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

引用

页码：140 / 150

页数：11

共 50 条

[41] Tracking Early Decline in Cognitive Function in Older Individuals at Risk for Alzheimer Disease Dementia The Alzheimer's Disease Cooperative Study Cognitive Function Instrument
Amariglio, Rebecca E.
Donohue, Michael C.
Marshall, Gad A.
Rentz, Dorene M.
Salmon, David P.
Ferris, Steven H.
Karantzoulis, Stella
Aisen, Paul S.
Sperling, Reisa A.
JAMA NEUROLOGY, 2015, 72 (04) : 446 - 454
[42] Alzheimer's disease genetic risk and changes in brain atrophy and white matter hyperintensities in cognitively unimpaired adults
Soldan, Anja
Wang, Jiangxia
Pettigrew, Corinne
Davatzikos, Christos
Erus, Guray
Hohman, Timothy J.
Dumitrescu, Logan
Bilgel, Murat
Resnick, Susan M.
Rivera-Rivera, Leonardo A.
Langhough, Rebecca
Johnson, Sterling C.
Benzinger, Tammie
Morris, John C.
Laws, Simon M.
Fripp, Jurgen
Masters, Colin L.
Albert, Marilyn S.
BRAIN COMMUNICATIONS, 2024, 6 (05)
[43] Development of Apathy, Anxiety, and Depression in Cognitively Unimpaired Older Adults: Effects of Alzheimer's Disease Pathology and Cognitive Decline
Johansson, Maurits
Stomrud, Erik
Johansson, Per Marten
Svenningsson, Anna
Palmqvist, Sebastian
Janelidze, Shorena
van Westen, Danielle
Mattsson-Carlgren, Niklas
Hansson, Oskar
BIOLOGICAL PSYCHIATRY, 2022, 92 (01) : 34 - 43
[44] Subjective Cognitive Decline and its Relation to Verbal Memory and Sex in Cognitively Unimpaired Individuals from a Colombian Cohort with Autosomal-Dominant Alzheimer's Disease
Martinez, Jairo E.
Pardilla-Delgado, Enmanuelle
Guzman-Velez, Edmarie
Vila-Castelar, Clara
Amariglio, Rebecca
Gatchel, Jennifer
Aguirre-Acevedo, Daniel C.
Bocanegra, Yamile
Baena, Ana
Henao, Eliana
Tirado, Victoria
Munoz, Claudia
Giraldo-Chica, Margarita
Lopera, Francisco
Quiroz, Yakeel T.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2022, 28 (06) : 541 - 549
[45] Association of Telomere Length With Risk of Disease and Mortality
Schneider, Carolin, V
Schneider, Kai Markus
Teumer, Alexander
Rudolph, Karl Lenhard
Hartmann, Daniel
Rader, Daniel J.
Strnad, Pavel
JAMA INTERNAL MEDICINE, 2022, 182 (03) : 291 - 300
[46] Cross-sectional and Longitudinal Analysis of the Relationship Between Aβ Deposition, Cortical Thickness, and Memory in Cognitively Unimpaired Individuals and in Alzheimer Disease
Dore, Vincent
Villemagne, Victor L.
Bourgeat, Pierrick
Fripp, Jurgen
Acosta, Oscar
Chetelat, Gael
Zhou, Luping
Martins, Ralph
Ellis, Kathryn A.
Masters, Colin L.
Ames, David
Salvado, Oliver
Rowe, Christopher C.
JAMA NEUROLOGY, 2013, 70 (07) : 903 - 911
[47] Retinal vascular fractal analysis in cognitively intact individuals at risk for Alzheimer's Disease
Graff, Jordan Taylor
Badr, Amro
Woodruff, Bryan
Caselli, Richard
Li, Xin
Sobczak, Jacob
Chen, John J.
Wang, Yalin
Dumitrascu, Oana
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
[48] Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
Smith, CD
Andersen, AH
Kryscio, RJ
Schmitt, FA
Kindy, MS
Blonder, LX
Avison, MJ
NEUROLOGY, 1999, 53 (07) : 1391 - 1396
[49] Telomere length, in vivo Alzheimer's disease pathologies and cognitive decline in older adults
Jung, Joon Hyung
Byun, Min Soo
Yi, Dahyun
Ahn, Hyejin
Lee, Jun Ho
Lee, Jang-Seok
Lee, Hyun-Seob
Lee, Jun-Young
Kim, Yu Kyeong
Lee, Yun-Sang
Kang, Koung Mi
Sohn, Chul-Ho
Lee, Dong Young
KBASE Research Group
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2024,
[50] Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older adults
Leffa, Douglas T.
Ferrari-Souza, Joao Pedro
Bellaver, Bruna
Tissot, Cecile
Ferreira, Pamela C. L.
Brum, Wagner S.
Caye, Arthur
Lord, Jodie
Proitsi, Petroula
Martins-Silva, Thais
Tovo-Rodrigues, Luciana
Tudorascu, Dana L.
Villemagne, Victor L.
Cohen, Ann D.
Lopez, Oscar L.
Klunk, William E.
Karikari, Thomas K.
Rosa-Neto, Pedro
Zimmer, Eduardo R.
Molina, Brooke S. G.
Rohde, Luis Augusto
Pascoal, Tharick A.
MOLECULAR PSYCHIATRY, 2023, 28 (03) : 1248 - 1255

← 1 2 3 4 5 →