How to explain the beneficial effects of leukocyte- and platelet-rich fibrin

被引：2
|
作者：
Blanco, Juan [1 ]
Alonso, Angel Garcia [2 ]
Hermida-Nogueira, Lidia [2 ]
Castro, Ana B. [3 ]
机构：
[1] Univ Santiago De Compostela, Dept Surg, Unit Periodontol, Stomatol, Rua Entrerrios 1, Santiago De Compostela 15705, Spain
[2] Santiago De Compostela Univ, Ctr Res Mol Med & Chron Dis CIMUS, Platelet Prote Grp, Santiago De Compostela, Spain
[3] KU Leuven & Dent, Univ Hosp Leuven, Sect Periodontol, Dept Oral Hlth Sci, Leuven, Belgium
来源：
PERIODONTOLOGY 2000 | 2024年
关键词：
analgesic; antibacterial; antimicrobial; bone healing; bone regeneration; hemostatic; leukocyte- and platelet-rich fibrin; pain; soft tissue regeneration; wound healing; 3RD MOLAR SURGERY; QUALITY-OF-LIFE; GROWTH-FACTORS; IN-VITRO; PLASMA RICH; BOVINE BONE; SOFT-TISSUE; L-PRF; POSTOPERATIVE COMPLICATIONS; ANTIMICROBIAL ACTIVITY;
D O I：
10.1111/prd.12570
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation and differentiation is driven by several growth factors and is critically dependent on the organization of the extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, growth factors, and cytokines are trapped and delivered over time, they are able to influence that response at different levels. The present review thoroughly describes the molecular components present in one of these APCs, leukocyte- and platelet-rich fibrin (L-PRF), and summarizes the level of evidence regarding the influence of L-PRF on anti-inflammatory reactions, analgesia, hemostasis, antimicrobial capacity, and its biological mechanisms on bone/soft tissue regeneration.
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页数：21
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