Pre-asthma: a useful concept? A EUFOREA paper. Part 2-late onset eosinophilic asthma

被引：1

作者：

Scadding, G. K. ^{[1
,2
]}

Gray, C. ^{[3
,4
]}

Conti, D. M. ^{[5
,6
]}

McDonald, M. ^{[7
]}

Backer, V. ^{[8
]}

Scadding, G. ^{[9
]}

Bernal-Sprekelsen, M. ^{[10
,11
]}

De Corso, E. ^{[12
]}

Diamant, Z. ^{[13
,14
,15
,16
,17
]}

Hopkins, C. ^{[18
]}

Jesenak, M. ^{[19
,20
,21
]}

Johansen, P. ^{[22
,23
]}

Kappen, J. ^{[24
]}

Mullol, J. ^{[25
,26
]}

Price, D. ^{[27
,28
]}

Quirce, S. ^{[29
]}

Reitsma, S. ^{[30
]}

Toppila-Salmi, S. ^{[31
,32
,33
,34
]}

Senior, B. ^{[35
]}

Thyssen, J. P. ^{[36
]}

Wahn, U. ^{[37
]}

Hellings, P. W. ^{[38
,39
,40
]}

机构：

[1] Royal Natl ENT Hosp, Dept Allergy & Rhinol, London, England

[2] UCL, Div Immun & Infect, London, England

[3] Univ Cape Town, Red Cross Childrens Hosp, Cape Town, South Africa

[4] Kidsallergy Ctr, Cape Town, South Africa

[5] European Forum Res & Educ Allergy & Airway Dis, Sci Expert Team Members, Brussels, Belgium

[6] Univ Autonoma Madrid, Escuela Doctorado UAM, Ctr Estudios Posgrad, C Francisco Tomas y Valiente 2, Madrid 28049, Spain

[7] Blairgowrie, Allergy Clin, Randburg, South Africa

[8] Univ Copenhagen, Dept Otorhinolaryngol Head & Neck Surg, Audiol, Rigshosp, Copenhagen, Denmark

[9] Royal Brompton Hosp, Allergy, London, England

[10] Clin Barcelona, Otolaryngol Dept, Barcelona, Spain

[11] Univ Barcelona, Otolaryngol Dept, Barcelona, Spain

[12] A Gemelli Univ Hosp Fdn IRCCS, Otolaryngol Head & Neck Surg, Rome, Italy

[13] Lund Univ, Skane Univ Hosp, Inst Clin Sci, Dept Resp Med & Allergol, Lund, Sweden

[14] Charles Univ Prague, Fac Med 1, Dept Resp Med, Prague, Czech Republic

[15] Thomayer Hosp, Prague, Czech Republic

[16] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[17] Katholieke Univ Leuven, Catholic Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium

[18] Guys & St ThomasHospital NHS Fdn Trust, Dept Rhinol & Skull Base Surg, London, England

[19] Univ Teaching Hosp Martin, Dept Clin Immunol & Allergol, Martin, Slovakia

[20] Comenius Univ, Univ Teaching Hosp Martin, Jessenius Fac Med Martin, Dept Paediat, Martin, Slovakia

[21] Comenius Univ, Univ Hosp Martin, Jessenius Fac Med Martin, Dept Pulmonol & Phthisiol, Martin, Slovakia

[22] Univ Zurich, Dept Dermatol, Zurich, Switzerland

[23] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland

[24] Franciscus Gasthuis & Vlietland, STZ Ctr Excellence Asthma, Dept Pulmonol, COPD & Resp Allergy, Rotterdam, Netherlands

[25] Univ Barcelona, Hosp Clin, ENT Dept, Rhinol Unit,FRCB IDIBAPS, Barcelona, Spain

[26] Univ Barcelona, Hosp Clin, ENT Dept, Smell Clin,FRCB IDIBAPS, Barcelona, Spain

[27] Observat & Pragmat Res Inst, Singapore, Singapore

[28] Univ Aberdeen, Ctr Acad Primary Care, Div Appl Hlth Sci, Aberdeen, Scotland

[29] La Paz Univ Hosp, Dept Allergy, IdiPAZ, Madrid, Spain

[30] Univ Amsterdam, Amsterdam Univ, Dept Otorhinolarynogol & Head Neck Surg, Med Ctr, Amsterdam, Netherlands

[31] Kuopio Univ Hosp, Dept Otorhinolaryngol, Kuopio, Finland

[32] Univ Eastern Finland, Kuopio, Finland

[33] Helsinki Univ Hosp, Inflammat Ctr, Dept Allergy, Helsinki, Finland

[34] Univ Helsinki, Helsinki, Finland

[35] Univ North Carolina Chapel Hill, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA

[36] Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol, Copenhagen, Denmark

[37] Charite, Dept Pediat Pneumol & Immunol, Berlin, Germany

[38] Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[39] Univ Hosp Leuven, Lab Allergy & Clin Immunol, Leuven, Belgium

[40] Univ Ghent, Dept Head & Skin, Upper Airways Res Lab, Ghent, Belgium

来源：

FRONTIERS IN ALLERGY | 2024年 / 5卷

关键词：

late onset asthma; non-allergic rhinitis; chronic rhinosinusitis with nasal polyps; eosinophils; mast cells; virulence genes; S. aureus biofilm; ENDOSCOPIC SINUS SURGERY; CHRONIC RHINOSINUSITIS; STAPHYLOCOCCUS-AUREUS; NASAL POLYPOSIS; NONALLERGIC RHINITIS; GLOBAL ALLERGY; POPULATION; IGE; ASSOCIATION; EXPOSURE;

D O I：

10.3389/falgy.2024.1404735

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in addition to the need to improve population health via multiple measures, including reduction of exposure to allergens and pollutants and avoidance of obesity, there are several possible specific means to reduce asthma development in those most at risk (pre- asthma). The most obvious is allergen immunotherapy (AIT), which when given for allergic rhinitis (AR) has reasonable evidence to support asthma prevention in children (2) but also needs further study as primary prevention. In this second paper we explore the possibilities for similar actions in late onset eosinophilic asthma.

引用

页数：12

共 2 条

[1] Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1-allergic asthma
Scadding, G. K.
McDonald, M.
Backer, V.
Scadding, G.
Bernal-Sprekelsen, M.
Conti, D. M.
De Corso, E.
Diamant, Z.
Gray, C.
Hopkins, C.
Jesenak, M.
Johansen, P.
Kappen, J.
Mullol, J.
Price, D.
Quirce, S.
Reitsma, S.
Salmi, S.
Senior, B.
Thyssen, J. P.
Wahn, U.
Hellings, P. W.
FRONTIERS IN ALLERGY, 2024, 4
[2] Effectiveness of Mepolizumab in patients with late-onset severe eosinophilic asthma and fixed obstruction, a 2-Year Follow-Up: The MESILICO study
Porpodis, Konstantinos
Tsiouprou, Ioanna
Damdoumis, Savvas
Bakakos, Petros
Steiropoulos, Paschalis
Voulgaris, Athanasios
Katsoulis, Konstantinos
Kipourou, Maria
Kostikas, Konstantinos
Antoniou, Katerina M.
Papaioannou, Andriana, I
Rovina, Nikoletta
Katsaounou, Paraskevi
Tryfon, Stavros
Fouka, Evangelia
Papakosta, Despoina
Loukides, Stelios
Domvri, Kalliopi
EUROPEAN RESPIRATORY JOURNAL, 2024, 64

← 1 →