Chitosan-collagen-cerium hydroxyapatite nanocomposites for In-vitro gentamicin drug delivery and antibacterial properties

被引:1
|
作者
Quilumbango, Amauta [1 ]
Briceno, Sarah [1 ]
Ponce, Juan Fernando [1 ]
Vizuete, Karla [3 ]
Debut, Alexis [3 ]
Botas, Javier Alvarez [2 ]
Gonzalez, Gema [1 ]
机构
[1] Yachay Tech Univ, Sch Phys Sci & Nanotechnol, Urcuqui 100119, Ecuador
[2] Yachay Tech Univ, Sch Biol Sci & Engn, Urcuqui 100119, Ecuador
[3] Univ Fuerzas Armadas ESPE, Ctr Nanociencia & Nanotecnol, Sangolqui, Ecuador
来源
CARBON TRENDS | 2024年 / 16卷
关键词
Gentamicin; Chitosan; Collagen; Hydroxyapatite; Nanocomposites; Antibacterial properties; RAMAN-SPECTROSCOPY; RELEASE; REGENERATION; PHOSPHATE; OXIDE; FTIR;
D O I
10.1016/j.cartre.2024.100392
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The controlled release of antibiotics is crucial to improving antimicrobial efficacy, reducing the risk of bacterial resistance, and ensuring a localized therapeutic effect. In this work, In-vitro Gentamicin release was studied using fluorescence chitosan collagen-cerium hydroxyapatite nanocomposites. Cerium-hydroxyapatite nanoparticles were synthesized using the hydrothermal method, and the nanocomposites were prepared by mixing chitosan-collagen-cerium hydroxyapatite at different weight ratios. Structural characterization was conducted using scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, and fluorescence microscopy. Ultraviolet-visible spectroscopy (UV-Vis) was used to quantify the release of gentamicin in simulated body fluid. Results showed that hydroxyapatite releases 90 % of gentamicin in the first 10 min, and the Chitosan-collagen-cerium hydroxyapatite nanocomposites release 80 % of gentamicin after 2 h. The antibacterial activity was studied against Escherichia coli (E. coli) at different time intervals. These nanocomposites can potentially improve the performance of biomedical applications.
引用
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页数:8
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