The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study

被引:1
|
作者
Warncke, Katharina [1 ,2 ,20 ]
Tamura, Roy [3 ]
Schatz, Desmond A. [4 ]
Veijola, Riitta [5 ,6 ]
Steck, Andrea K. [7 ]
Akolkar, Beena [8 ]
Hagopian, William [9 ]
Krischer, Jeffrey P. [3 ]
Lernmark, Ake [10 ]
Rewers, Marian J. [7 ]
Toppari, Jorma [11 ,12 ,13 ,14 ]
McIndoe, Richard [15 ]
Ziegler, Anette-G [2 ,16 ,17 ,18 ]
Vehik, Kendra [3 ]
Haller, Michael J. [19 ]
Larsson, Helena Elding
机构
[1] Tech Univ Munich, TUM Sch Med, Dept Pediat, D-81675 Munich, Germany
[2] Helmholtz Munich, Inst Diabet Res, German Ctr Environm Hlth, D-80939 Munich, Germany
[3] Univ S Florida, Hlth Informat Inst, Tampa, FL 33612 USA
[4] Univ Florida, Diabet Ctr Excellence, Gainesville, FL 32610 USA
[5] Univ Oulu, Dept Pediat, Res Unit Clin Med, Med Res Ctr Oulu, Oulu 90014, Finland
[6] Oulu Univ Hosp, Oulu 90014, Finland
[7] Univ Colorado, Barbara Davis Ctr Diabet, Anschutz Med Campus, Aurora, CO 80045 USA
[8] Natl Inst Diabet & Digest & Kidney Dis, Bethesda, MD 20892 USA
[9] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA
[10] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo 21428, Sweden
[11] Univ Turku, Dept Pediat, Turku 20521, Finland
[12] Turku Univ Hosp, Turku 20520, Finland
[13] Univ Turku, Inst Biomed, Res Ctr Integrat Physiol & Pharmacol, FI-20520 Turku, Finland
[14] Univ Turku, Ctr Populat Hlth Res, Turku 20520, Finland
[15] Augusta Univ, Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA
[16] German Ctr Diabet Res DZD, D-85764 Munich Neuherberg, Germany
[17] Tech Univ Munich, Sch Med, Klinikum Rechts Isar, Forschergruppe Diabet, D-81675 Munich, Germany
[18] German Res Ctr Environm Hlth, Helmholtz Munich, Forschergruppe Diabet eV, D-80939 Munich, Germany
[19] Univ Florida, Diabet Inst, Coll Med, Dept Pediat, Gainesville, FL 32610 USA
[20] Tech Univ Munich, Dept Pediat, Kinderklin Munchen Schwabing, Sch Med, Kolner Pl 1, D-80804 Munich, Germany
关键词
diabetes; beta-cell; insulin resistance; type; 1; INSULIN-RESISTANCE; ENVIRONMENTAL DETERMINANTS; SELF-ASSESSMENT; YOUNG TEDDY; CHILDREN; RISK; AGE; MATURATION; ONSET;
D O I
10.1210/jendso/bvae103
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty. Objective: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes. Methods: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios. Results: Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage >= 2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; P = .019) for incident autoimmunity than prepubertal children (Tanner Stage 1). An increase of body mass index Z-score was associated with a higher risk (HR 2.88, 95% CI 1.61-5.15; P < .001) of incident insulin autoantibodies. In children with multiple autoantibodies, neither HOMA-IR nor rate of progression to Tanner Stage 4 were associated with progression to type 1 diabetes. Conclusion Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Staging and monitoring progression to type 1 diabetes with islet autoantibody characteristics
    Achenbach, P
    Warncke, K
    Reiter, J
    Williams, A
    Bingley, P
    Bonifacio, E
    Ziegler, AG
    DIABETES, 2005, 54 : A312 - A312
  • [22] Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)
    Steck, Andrea K.
    Vehik, Kendra
    Bonifacio, Ezio
    Lernmark, Ake
    Ziegler, Anette-G.
    Hagopian, William A.
    She, JinXiong
    Simell, Olli
    Akolkar, Beena
    Krischer, Jeffrey
    Schatz, Desmond
    Rewers, Marian J.
    DIABETES CARE, 2015, 38 (05) : 808 - 813
  • [23] Loss of multiple islet autoantibody status during progression to type 1 diabetes
    Simmons, K.
    Dong, F.
    Waugh, K.
    Yu, L.
    Rewers, M.
    HORMONE RESEARCH IN PAEDIATRICS, 2024, 97 : 52 - 52
  • [24] Loss of Multiple Islet Autoantibody Status during Progression to Type 1 Diabetes
    Simmons, Kimber M.
    Dong, Fran
    Waugh, Kathleen
    Yu, Liping
    Rewers, Marian
    DIABETES, 2024, 73
  • [25] HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
    Salami, Falastin
    Tamura, Roy
    You, Lu
    Lernmark, Ake
    Larsson, Helena Elding
    Lundgren, Markus
    Krischer, Jeffrey
    Ziegler, Anette-Gabriele
    Toppari, Jorma
    Veijola, Riitta
    Rewers, Marian
    Haller, Michael J.
    Hagopian, William
    Akolkar, Beena
    Torn, Carina
    PEDIATRIC DIABETES, 2022, 23 (08) : 1586 - 1593
  • [26] Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study
    Lee, Hye-Seung
    Burkhardt, Brant R.
    McLeod, Wendy
    Smith, Susan
    Eberhard, Chris
    Lynch, Kristian
    Hadley, David
    Rewers, Marian
    Simell, Olli
    She, Jin-Xiong
    Hagopian, Bill
    Lernmark, Ake
    Akolkar, Beena
    Ziegler, Anette G.
    Krischer, Jeffrey P.
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2014, 30 (05) : 424 - 434
  • [27] Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study
    Vehik, Kendra
    Lynch, Kristian F.
    Schatz, Desmond A.
    Akolkar, Beena
    Hagopian, William
    Rewers, Marian
    She, Jin-Xiong
    Simell, Olli
    Toppari, Jorma
    Ziegler, Anette-G.
    Lernmark, Ake
    Bonifacio, Ezio
    Krischer, Jeffrey P.
    DIABETES CARE, 2016, 39 (09) : 1535 - 1542
  • [28] Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study
    Beyerlein, Andreas
    Bonifacio, Ezio
    Vehik, Kendra
    Hippich, Markus
    Winkler, Christiane
    Frohnert, Brigitte I.
    Steck, Andrea K.
    Hagopian, William A.
    Krischer, Jeffrey P.
    Lernmark, Ake
    Rewers, Marian J.
    She, Jin-Xiong
    Toppari, Jorma
    Akolkar, Beena
    Rich, Stephen S.
    Ziegler, Anette-G
    JOURNAL OF MEDICAL GENETICS, 2019, 56 (09) : 602 - 605
  • [29] Progression to type 1 diabetes and autoantibody positivity in relation to HLA risk genotypes in children participating in the ABIS study
    Gullstrand, C.
    Wahlberg, J.
    Ilonen, J.
    Vaarala, O.
    Ludvigsson, J.
    DIABETOLOGIA, 2006, 49 : 179 - 180
  • [30] In people with suspected type 1 diabetes or rapid progression to insulin, a single positive islet autoantibody confirms the genetic characteristics and progression of classical type 1 diabetes
    Simpson, V. E.
    Thomas, N.
    Hill, A. V.
    Deshmukh, S.
    Shields, B. M.
    McDonald, T.
    Jones, A. G.
    DIABETIC MEDICINE, 2022, 39