The Effects of Pre-Fusion Probability Calibration

被引:0
|
作者
Harris, Daniel [1 ]
Lovassy, Peter [2 ]
Dunham, Darin [2 ]
机构
[1] Northrop Grumman, Morrisville, NC 27560 USA
[2] Lockheed Martin, Huntsville, AL USA
关键词
D O I
10.1109/AERO58975.2024.10521204
中图分类号
V [航空、航天];
学科分类号
08 ; 0825 ;
摘要
Quite often the state of information provided by disparate sources, or experts, is not conducive to fusion without additional pre-fusion processing. The focus of this paper involves testing the effects of two pre-processing steps to help illustrate the contribution of each to performance, and also testing two different fusion methods to illustrate how robust each are against lacking/imperfect pre-processing steps. The pre-processing steps, which are the focus of this study, are two calibration steps. The first calibrates overconfident expert information, and the second calibrates for track-to-track association ambiguity. The two fusion methods tested areWeighted Conflict Redistribution (WCR) Rule number 0-or WCR0 for short, and is also known as Dempster's rule-and WCR2. WCR0 continues to produce the optimal fusion solution when both pre-processing calibration steps are performed perfectly, and yet, it is shown to be significantly less robust given significant miscalibration in the source probabilities.
引用
收藏
页数:8
相关论文
共 50 条
  • [11] Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability
    Webb, Stacy
    Nagy, Tamas
    Moseley, Hunter
    Fried, Michael
    Dutch, Rebecca
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (14) : 5685 - 5694
  • [12] GTP binding, but not hydrolysis, is required for the atlastin 'pre-fusion' to 'post-fusion' transition
    Morin-Leisk, J. H.
    Saini, S. G.
    Lee, T. H.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [13] Development of a High Yielding Bioprocess for a Pre-fusion RSV Subunit Vaccine
    Chen, Peifeng
    Chen, Mingzhong
    Menon, Amritha
    Hussain, Althaf, I
    Carey, Elizabeth
    Lee, Christopher
    Horwitz, Joe
    O'Connell, Sarah
    Cooper, Johnathan W.
    Schwartz, Richard
    Gowetski, Daniel B.
    JOURNAL OF BIOTECHNOLOGY, 2021, 325 : 269 - 278
  • [14] Fusion Protein TM-TM Interactions: Modulators of Pre-Fusion Protein Stability
    Webb, Stacy
    Dutch, Rebecca
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 388A - 388A
  • [15] PHOSPHORYLATION OF PRE-FUSION MYOBLAST MYOSIN INCREASES ACTIN-ACTIVATION
    SCORDILIS, SP
    ADELSTEIN, RS
    BIOPHYSICAL JOURNAL, 1977, 17 (02) : A268 - A268
  • [16] Crystal structure of Usutu virus envelope protein in the pre-fusion state
    Zimin Chen
    Fei Ye
    Sheng Lin
    Fanli Yang
    Yanwei Cheng
    Yu Cao
    Zhujun Chen
    Guangwen Lu
    Virology Journal, 15
  • [17] Stalking influenza by vaccination with pre-fusion headless HA mini-stem
    Valkenburg, Sophie A.
    Mallajosyula, V. Vamsee Aditya
    Li, Olive T. W.
    Chin, Alex W. H.
    Carnell, George
    Temperton, Nigel
    Varadarajan, Raghavan
    Poon, Leo L. M.
    SCIENTIFIC REPORTS, 2016, 6
  • [18] Crystal structure of Usutu virus envelope protein in the pre-fusion state
    Chen, Zimin
    Ye, Fei
    Lin, Sheng
    Yang, Fanli
    Cheng, Yanwei
    Cao, Yu
    Chen, Zhujun
    Lu, Guangwen
    VIROLOGY JOURNAL, 2018, 15
  • [19] Stalking influenza by vaccination with pre-fusion headless HA mini-stem
    Sophie A. Valkenburg
    V. Vamsee Aditya Mallajosyula
    Olive T. W. Li
    Alex W. H. Chin
    George Carnell
    Nigel Temperton
    Raghavan Varadarajan
    Leo L. M. Poon
    Scientific Reports, 6
  • [20] A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
    Jarrod J. Mousa
    Nurgun Kose
    Pranathi Matta
    Pavlo Gilchuk
    James E. Crowe
    Nature Microbiology, 2