QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE

被引：0
|
作者：
Dou, Jinfang [1 ]
Zhang, Xin 'ai [2 ]
Hu, Chaoqun [1 ]
Gao, Yuqian [3 ]
Zhao, Yue [3 ]
Hei, Murong [3 ]
Wang, Zhimiao [1 ]
Guo, Nan [3 ]
Zhu, Haiyan [1 ,3 ]
机构：
[1] Beijing Univ Chinese Med, Beijing, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
[3] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China
来源：
EXPERIMENTAL GERONTOLOGY | 2024年 / 190卷
基金：
中国国家自然科学基金;
关键词：
beta-Amyloid; QKL injection; Receptor for advanced glycation end products; Network pharmacology; Molecular docking; AMYLOID-BETA; SYNAPTIC DAMAGE; STRESS; BRAIN; MODEL;
D O I：
10.1016/j.exger.2024.112422
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The onset of Alzheimer's disease is related to neuron damage caused by massive deposition of A beta in the brain. Recent studies suggest that excessive A beta in the brain mainly comes from peripheral blood, and BBB is the key to regulate A beta in and out of the brain. In this study, we explored the pathogenesis of AD from the perspective of A beta transport through the BBB and the effect of QKL injection in AD mice. The results showed that QKL could improve the cognitive dysfunction of AD mice, decrease the level of A beta and A beta transporter-RAGE, which was supported by the results of network pharmacology, molecular docking and molecular dynamics simulation. In conclusion, RAGE is a potential target for QKL's therapeutic effect on AD.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats
    Tyumentsev, Mikhail A.
    Stefanova, Natalia A.
    Muraleva, Natalia A.
    Rumyantseva, Yulia, V
    Kiseleva, Elena
    Vavilin, Valentin A.
    Kolosova, Nataliya G.
    JOURNAL OF ALZHEIMERS DISEASE, 2018, 63 (03) : 1075 - 1088
  • [32] Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain
    Bates, Kristyn
    Vink, Robert
    Martins, Ralph
    Harvey, Alan
    NEUROBIOLOGY OF AGING, 2014, 35 (06) : 1345 - 1351
  • [33] Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology
    Laurent, Cyril
    Eddarkaoui, Sabiha
    Derisbourg, Maxime
    Leboucher, Antoine
    Demeyer, Dominique
    Carrier, Sebastien
    Schneider, Marion
    Hamdane, Malika
    Mueller, Christa E.
    Buee, Luc
    Blum, David
    NEUROBIOLOGY OF AGING, 2014, 35 (09) : 2079 - 2090
  • [34] Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates
    Forny-Germano, Leticia
    Lyra e Silva, Natalia M.
    Batista, Andre F.
    Brito-Moreira, Jordano
    Gralle, Matthias
    Boehnke, Susan E.
    Coe, Brian C.
    Lablans, Ann
    Marques, Suelen A.
    Martinez, Ana Maria B.
    Klein, William L.
    Houzel, Jean-Christophe
    Ferreira, Sergio T.
    Munoz, Douglas P.
    De Felice, Fernanda G.
    JOURNAL OF NEUROSCIENCE, 2014, 34 (41): : 13629 - 13643
  • [35] Association of cerebrovascular dysfunction with the development of Alzheimer’s disease-like pathology in OXYS rats
    Natalia A. Stefanova
    Kseniya Yi Maksimova
    Ekaterina A. Rudnitskaya
    Natalia A. Muraleva
    Nataliya G. Kolosova
    BMC Genomics, 19
  • [36] Treadmill Exercise Prevents Learning and Memory Impairment in Alzheimer's Disease-Like Pathology
    Dao, An T.
    Zagaar, Munder A.
    Levine, Amber T.
    Salim, Samina
    Eriksen, Jason L.
    Alkadhi, Karim A.
    CURRENT ALZHEIMER RESEARCH, 2013, 10 (05) : 507 - 515
  • [37] Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
    David Baglietto-Vargas
    Stefania Forner
    Lena Cai
    Alessandra C. Martini
    Laura Trujillo-Estrada
    Vivek Swarup
    Marie Minh Thu Nguyen
    Kelly Do Huynh
    Dominic I. Javonillo
    Kristine Minh Tran
    Jimmy Phan
    Shan Jiang
    Enikö A. Kramár
    Cristina Nuñez-Diaz
    Gabriela Balderrama-Gutierrez
    Franklin Garcia
    Jessica Childs
    Carlos J. Rodriguez-Ortiz
    Juan Antonio Garcia-Leon
    Masashi Kitazawa
    Mohammad Shahnawaz
    Dina P. Matheos
    Xinyi Ma
    Celia Da Cunha
    Ken C. Walls
    Rahasson R. Ager
    Claudio Soto
    Antonia Gutierrez
    Ines Moreno-Gonzalez
    Ali Mortazavi
    Andrea J. Tenner
    Grant R. MacGregor
    Marcelo Wood
    Kim N. Green
    Frank M. LaFerla
    Nature Communications, 12
  • [38] An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology
    Stefanova, Natalia A.
    Muraleva, Natalia A.
    Maksimova, Kseniya Yi.
    Rudnitskaya, Ekaterina A.
    Kiseleva, Elena
    Telegina, Darya V.
    Kolosova, Nataliya G.
    AGING-US, 2016, 8 (11): : 2713 - 2733
  • [39] Azilsartan ameliorates aluminium chloride induced Alzheimer's disease like pathology
    Mishra, Sunita
    Prusty, Shakti Ketan
    Sahu, Pratap Kumar
    Das, Debajyoti
    CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES, 2023, 36 (03) : 151 - 157
  • [40] Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer’s Disease-Like Pathology, Blood–Brain Barrier Disruption, and Synaptic Disorder
    Pradip K. Kamat
    Philip Kyles
    Anuradha Kalani
    Neetu Tyagi
    Molecular Neurobiology, 2016, 53 : 2451 - 2467
12345