Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting

被引:0
|
作者
Rutt, Lauren N. [1 ]
Liu, Mengfei [2 ]
Melamed, Esther [3 ]
Twardy, Shannon [1 ]
Sturgill, Jamie L. [4 ]
Brenner, Lisa A. [5 ,6 ,7 ,8 ,9 ,10 ,11 ]
Hardesty, Josiah [12 ]
Weinman, Steven A. [13 ]
Tschann, Madison M. [14 ,15 ]
Travers, Jared [16 ,17 ,18 ]
Welsh, David A. [19 ]
Chichetto, Natalie [20 ]
Crotty, Kathryn M. [21 ,22 ]
Mackowiak, Bryan [23 ]
Yeligar, Samantha M. [21 ,22 ]
Wyatt, Todd A. [24 ,25 ,26 ]
McMahan, Rachel H. [27 ]
Choudry, Mashkoor A. [14 ,15 ]
Kovacs, Elizabeth J. [27 ,28 ,29 ]
McCullough, Rebecca L. [1 ,29 ,30 ]
机构
[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA
[2] Yale Sch Med, Digest Dis, New Haven, CT USA
[3] Univ Texas Austin, Dept Neurol, Austin, TX USA
[4] Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY USA
[5] VA Rocky Mt Mental Illness Res Educ & Clin Ctr, Rocky Mt Reg Vet Affairs VA Med Ctr, Aurora, CO USA
[6] Univ Colorado, Dept Phys Med & Rehabil, Anschutz Med Campus, Aurora, CO USA
[7] Univ Colorado, Dept Psychiat & Neurol, Anschutz Med Campus, Aurora, CO USA
[8] Mil & Vet Microbiome Consortium Res & Educ, Aurora, CO USA
[9] Univ Colorado, Dept Phys Med & Rehabil, Anschutz Med Campus, Aurora, CO USA
[10] Univ Colorado, Dept Psychiat, Anschutz Med Campus, Aurora, CO USA
[11] Univ Colorado, Dept Neurol, Anschutz Med Campus, Aurora, CO USA
[12] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY USA
[13] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, MO USA
[14] Loyola Univ Chicago, Dept Surg, Hlth Sci Campus, Maywood, IL USA
[15] Loyola Univ Chicago, Alcohol Res Program, Hlth Sci Campus, Maywood, IL USA
[16] Case Western Reserve Univ, Div Gastroenterol & Liver Dis, Cleveland, OH USA
[17] Univ Hosp Cleveland Med Ctr, Cleveland, OH USA
[18] Lerner Res Inst, Dept Inflammat & Immun, Cleveland Clin, Cleveland, OH USA
[19] Louisiana State Univ, Hlth Sci Ctr, Dept Med, Sect Pulm & Crit Care Med, New Orleans, LA USA
[20] Univ Florida, Coll Med, Coll Publ Hlth & Hlth Profess, Dept Epidemiol, Gainesville, FL USA
[21] Emory Univ, Dept Med, Div Pulm Allergy Crit Care & Sleep, Atlanta, GA USA
[22] Atlanta Vet Affairs Med Ctr, Decatur, GA USA
[23] Natl Inst Alcohol Abuse & Alcoholism, Lab Liver Dis, NIH, Bethesda, MD USA
[24] Univ Nebraska, Med Ctr, Dept Internal Med, Pulm Crit Care Sleep & Allergy Div, Omaha, NE USA
[25] Vet Affairs Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE USA
[26] Univ Nebraska Med Ctr, Coll Publ Hlth, Dept Environm Agr & Occupat Hlth, Omaha, NE USA
[27] Univ Colorado, Sch Med, Dept Surg, Div GI Trauma & Endocrine Surg, Anschutz Med Campus, Aurora, CO USA
[28] Eastern Colorado Hlth Care Syst, Rocky Mt Reg Vet Affairs Med Ctr RMRVAMC, Vet Hlth Adm, Aurora, CO USA
[29] Univ Colorado, Sch Med, Alcohol Res Program, Anschutz Med Campus, Aurora, CO USA
[30] Univ Colorado, Anschutz Med Campus,13850 E Montview Blvd,BoxC238-, Aurora, CO 80045 USA
关键词
Alcohol; Immunometabolism; Complosome; Immunoglobulins; Infection; ALVEOLAR MACROPHAGES; LIVER-INJURY; CONSUMPTION; STRESS; DISORDER;
D O I
10.1016/j.alcohol.2024.04.002
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
On December 8th 2023, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. The 2023 meeting focused broadly on how acute and chronic alcohol exposure leads to immune dysregulation, and how this contributes to damage in multiple tissues and organs. These include impaired lung immunity, intestinal dysfunction, autoimmunity, the gut-Central Nervous System (CNS) axis, and end-organ damage. In addition, diverse areas of alcohol research covered multiple pathways behind alcohol-induced cellular dysfunction, including inflammasome activation, changes in miRNA expression, mitochondrial metabolism, gene regulation, and transcriptomics. Finally, the work presented at this meeting high- lighted novel biomarkers and therapeutic interventions for patients suffering from alcohol -induced organ damage. (c) 2024 Elsevier Inc. All rights reserved.
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页码:9 / 16
页数:8
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