A Jaw-Dropping Consequence: Nintedanib's Role in Osteonecrosis of the Jaw

被引：0

作者：

Rai, Oshin ^{[1
]}

Romero, Kaitlyn N. ^{[1
]}

Shaykh, Natalie ^{[1
]}

Caldas, Ricardo ^{[1
]}

Tripathi, Vanshika ^{[1
]}

Padilla, Rebekah M. ^{[2
]}

Karan, Abhinav ^{[1
]}

Guo, Hui Jun ^{[1
]}

Jacob, Rafik ^{[3
]}

机构：

[1] Univ Florida, Coll Med Jacksonville, Internal Med, Jacksonville, FL 32209 USA

[2] Univ Florida, Coll Med Jacksonville, Diagnost Radiol, Jacksonville, FL USA

[3] Univ Florida, Coll Med Jacksonville, Program Adults Intellectual & Dev Disabil, Jacksonville, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 07期

关键词：

idiopathic pulmonary fibrosis and its comorbidities; ipf; osteonecrosis of the jaw; medication-related osteonecrosis of the jaw; nintedanib;

D O I：

10.7759/cureus.65689

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nintedanib, a tyrosine kinase inhibitor, is a cornerstone in the management of idiopathic pulmonary fibrosis through its anti-fibrotic effects; however, its impact on wound healing is less studied. We present a case of medication-related osteonecrosis of the jaw (MRONJ) following the initiation of nintedanib. The patient's presentation prompted a drug holiday of nintedanib, resulting in a marked improvement in her symptoms. MRONJ is a disease requiring a high index of suspicion, and the number of inciting medications continues to rise. Nintedanib, as an inhibitor of angiogenesis, may have contributed to poor wound healing following dental extraction, subsequently leading to MRONJ.

引用

页数：7

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